Sequential injection spectrophotometric determination of phenylephrine hydrochloride in pharmaceutical preparations

被引：21

作者：

Beyene, NW ^{[1
]}

Van Staden, JF ^{[1
]}

机构：

[1] Univ Pretoria, Dept Chem, ZA-0002 Pretoria, South Africa

来源：

TALANTA | 2004年 / 63卷 / 03期

关键词：

flow systems; sympathomimetic drugs; nasal decongestants; ophthalmic solutions;

D O I：

10.1016/j.talanta.2003.11.041

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

A fully automated sequential injection spectrophotometric method for the determination of phenylephrine hydrochloride in pharmaceutical preparations is reported. The method is based on the condensation reaction of the analyte with 4-aminoantipyrine in the presence of potassium ferricyanide. The absorbance of the condensation product was monitored at 503 nm. A linear relationship between the relative peak height and concentration was obtained in the range 0.5-17.5 mg l(-1). The detection limit (as 3sigma value) was 0.09 mg l(-1) and repeatability was 0.8 and 0.6% at 2.5 and 5 mg l(-1), respectively. Results obtained by this method agreed very well with those obtained by the AOAC official method. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：599 / 604

页数：6