Ecdysone-controlled expression of transgenes

被引：21

作者：

Graham, LD ^{[1
]}

机构：

[1] CSIRO, Sydney Lab, N Ryde, NSW 1670, Australia

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2002年 / 2卷 / 05期

关键词：

diacythydrazine; dibenzoylhydrazine; ecdysone receptor; ecdysteroid; GS-E; gene therapy; inducible regulatable expression; muristerone; ponasterone; RH-5992; retinoid-X receptor; tebufenozide;

D O I：

10.1517/14712598.2.5.525

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Inducible expression systems show great potential for use in human gene therapy and systems based on insect ecdysone receptors are particularly promising candidates. This article describes such systems and reviews actual and potential uses of ecdysone-controlled transgenes in vitro and in vivo. The ligand specificity of ecdysone receptor-based systems is considered, along with the safety and efficacy of the ecdysteroid and non-steroidal compounds used to activate them.

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收藏

页码：525 / 535

页数：11

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