CTLA4IgG gene delivery prevents autoantibody production and lupus nephritis in MRL/lpr mice

被引：44

作者：

Takiguchi, M

Murakami, M

Nakagawa, I

Saito, I

Hashimoto, A

Uede, T

机构：

[1] Hokkaido Univ, Inst Immunol Sci, Sect Immunopathogenesis, Sapporo, Hokkaido 0600815, Japan

[2] Hokkaido Univ, Grad Sch Vet Med, Dept Vet Clin Sci, Sapporo, Hokkaido 0600818, Japan

[3] Univ Tokyo, Inst Med Sci, Tokyo 1080071, Japan

来源：

LIFE SCIENCES | 2000年 / 66卷 / 11期

关键词：

CTLA4IgG; adenovirus vector; gene therapy; lupus; MRL/lpr mice;

D O I：

10.1016/S0024-3205(99)00664-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

MRL/MP-lpr/lpr (MRL/lpr) mice spontaneously develop an autoimmune syndrome closely resembling systemic lupus erythematosus (SLE) in humans, characterized by hypergammaglobulinemia, various autoantibody production, and the development of fatal glomerulonephritis. We have previously demonstrated that systemic administration of soluble form of CTLA4IgG prevented autoantibody-related diseases in MRL/lpr mice. To test the potential protective effects of CTLA4IgG gene delivery on the development of lupus nephritis, we injected MRL/lpr mice with, a recombinant adenovirus vector containing CTLA4IgG gene, Adex1CACTLA4IgG (AdCTLA4IgG). It was demonstrated that a single administration of intravenous injection of AdCTLA4IgG into MRL/lpr mice resulted in almost complete amelioration of lupus nephritis.

引用

页码：991 / 1001

页数：11

共 41 条

[1]

ABERRANT TRANSCRIPTION CAUSED BY THE INSERTION OF AN EARLY TRANSPOSABLE ELEMENT IN AN INTRON OF THE FAS ANTIGEN GENE OF LPR MICE [J].