Amplified benefit of Clopidogrel versus aspirin in patients with diabetes mellitus

被引：311

作者：

Bhatt, DL

Marso, SP

Hirsch, AT

Ringleb, PA

Hacke, W

Topol, EJ

机构：

[1] Cleveland Clin Fdn, Dept Cardiovasc Med, Cleveland, OH 44195 USA

[2] Mid Amer Heart Inst, Kansas City, MO USA

[3] Univ Minnesota, Sch Med, Vasc Med Program, Minneapolis, MN 55455 USA

[4] Univ Heidelberg, Sch Med, Dept Neurol, Heidelberg, Germany

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 90卷 / 06期

关键词：

D O I：

10.1016/S0002-9149(02)02567-5

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

An analysis of the 3,866 diabetic patients from the CAPRIE study revealed that they had a much higher rate of recurrent ischemic events than nondiabetic patients and that the benefit of clopidogrel over aspirin was amplified in the diabetic cohort. The level of risk and degree of benefit were highest in those diabetic patients who received insulin therapy.

引用

收藏

页码：625 / +

页数：5

相关论文

共 20 条

[1]

The influence of diabetes mellitus on acute and late clinical outcomes following coronary stent implantation [J].

Abizaid, A ;

Kornowski, R ;

Mintz, GS ;

Hong, MK ;

Abizaid, AS ;

Mehran, R ;

Pichard, AD ;

Kent, KM ;

Satler, LF ;

Wu, HS ;

Popma, JJ ;

Leon, MB .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (03) :584-589

[2]

Mechanisms determining course and outcome of diabetic patients who have had acute myocardial infarction [J].

Aronson, D ;

Rayfield, EJ ;

Chesebro, JH .

ANNALS OF INTERNAL MEDICINE, 1997, 126 (04) :296-306

[3]

Baigent C, 2002, BMJ-BRIT MED J, V324, P71, DOI 10.1136/bmj.324.7329.71

[4]

Relationship between diabetes mellitus and long-term survival after coronary bypass and angioplasty [J].

Barsness, GW ;

Peterson, ED ;

Ohman, EM ;

Nelson, CL ;

DeLong, ER ;

Reves, JG ;

Smith, PK ;

Anderson, RD ;

Jones, RH ;

Mark, DB ;

Califf, RM .

CIRCULATION, 1997, 96 (08) :2551-2556

[5]

Effect of diabetes mellitus and insulin use on survival after acute myocardial infarction in the elderly (The Cooperative Cardiovascular Project) [J].

Berger, AK ;

Breall, JA ;

Gersh, BJ ;

Johnson, AE ;

Oetgen, WJ ;

Marciniak, TA ;

Schulman, KA .

AMERICAN JOURNAL OF CARDIOLOGY, 2001, 87 (03) :272-277

[6]

Abciximab reduces mortality in diabetics following percutaneous coronary intervention [J].

Bhatt, DL ;

Marso, SP ;

Lincoff, AM ;

Wolski, KE ;

Ellis, SG ;

Topol, EJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 35 (04) :922-928

[7]

Reduction in the need for hospitalization for recurrent ischemic events and bleeding with clopidogrel instead of aspirin [J].

Bhatt, DL ;

Hirsch, AT ;

Ringleb, PA ;

Hacke, W ;

Topol, EJ .

AMERICAN HEART JOURNAL, 2000, 140 (01) :67-73

[8]

Davi G, 1997, CIRCULATION, V96, P69

[9]

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE) [J].

Gent, M ;

Beaumont, D ;

Blanchard, J ;

Bousser, MG ;

Coffman, J ;

Easton, JD ;

Hampton, JR ;

Harker, LA ;

Janzon, L ;

Kusmierek, JJE ;

Panak, E ;

Roberts, RS ;

Shannon, JS ;

Sicurella, J ;

Tognoni, G ;

Topol, EJ ;

Verstraete, M ;

Warlow, C .

LANCET, 1996, 348 (9038) :1329-1339

[10]

One-year outcomes of diabetic versus nondiabetic patients with non-Q-wave acute myocardial infarction treated with percutaneous transluminal coronary angioplasty [J].

Gowda, MS ;

Vacek, JL ;

Hallas, D .

AMERICAN JOURNAL OF CARDIOLOGY, 1998, 81 (09) :1067-1071