Baicalin Reverses Depressive-Like Behaviours and Regulates Apoptotic Signalling Induced by Olfactory Bulbectomy

被引：42

作者：

Yu, Hai-Yang ^{[1
]}

Yin, Zhu-Jun ^{[2
]}

Yang, Shui-Jin ^{[2
]}

Ma, Shi-Ping ^{[2
]}

Qu, Rong ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Discipline Chinese & Western Integrat Med, Hanzhonglu 282, Nanjing 210046, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2016年 / 30卷 / 03期

关键词：

baicalin; Apaf-1; caspase-9; caspase-3; apoptosis; olfactory bulbectomy; OXYGEN-GLUCOSE DEPRIVATION; RAT-BRAIN; NEURONAL DIFFERENTIATION; CYTOCHROME-C; STRESS; MODEL; ACTIVATION; CELLS; ANTIOXIDANT; RELEASE;

D O I：

10.1002/ptr.5550

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Apoptosis is thought to be involved in neurological disorders including major depression. In this study, we examined whether the polyphenolic compound baicalin could decrease apoptosis in the olfactory bulbectomy (OBX) depression rat model. OBX rats exhibited decreased performance in depression-like behavioural tests and showed evidence of increased oxidative stress, decreased synaptophysin expression, and hippocampal apoptosis. Treatment with baicalin (20 and 40mg/kg) significantly reversed all of these changes. Baicalin modulated the levels or activity of malondialdehyde, superoxide dismutase, and glutathione peroxidase and prevented apoptotic protease-activating factor-1 expression, effectively suppressing caspase-mediated apoptosis signalling cascades. Our results demonstrate that baicalin has potent antidepressant activity, likely because of its ability to suppress apoptosis. Copyright (c) 2015 John Wiley & Sons, Ltd.

引用

页码：469 / 475

页数：7

共 32 条

[1]

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