Amyloid and its association with default network integrity in Alzheimer's disease

被引：44

作者：

Adriaanse, Sofie M. ^{[1
]}

Sanz-Arigita, Ernesto J. ^{[2
,3
]}

Binnewijzend, Maja A. A. ^{[2
]}

Ossenkoppele, Rik ^{[1
]}

Tolboom, Nelleke ^{[1
]}

van Assema, Danielle M. E. ^{[1
]}

Wink, Alle Meije ^{[2
]}

Boellaard, Ronald ^{[1
]}

Yaqub, Maqsood ^{[1
]}

Windhorst, Albert D. ^{[1
]}

van der Flier, Wiesje M. ^{[4
]}

Scheltens, Philip ^{[4
]}

Lammertsma, Adriaan A. ^{[1
]}

Rombouts, Serge A. R. B. ^{[5
,6
,7
]}

Barkhof, Frederik ^{[2
]}

van Berckel, Bart N. M. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Nucl Med & PET Res, Alzheimer Ctr Amsterdam, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Radiol, Alzheimer Ctr Amsterdam, NL-1007 MB Amsterdam, Netherlands

[3] CITA Alzheimer Fdn, Dept Neuroimage, San Sebastian, Spain

[4] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Alzheimer Ctr Amsterdam, NL-1007 MB Amsterdam, Netherlands

[5] Leiden Univ, Inst Psychol, Leiden, Netherlands

[6] Leiden Univ, Med Ctr, Leiden Inst Brain & Cognit, Leiden, Netherlands

[7] Leiden Univ, Med Ctr, Dept Radiol, Leiden, Netherlands

来源：

HUMAN BRAIN MAPPING | 2014年 / 35卷 / 03期

关键词：

magnetic resonance imaging; positron emission tomography; default mode network; Alzheimer disease; resting-state fMRI; mild cognitive impairment; amyloid; STATE FUNCTIONAL CONNECTIVITY; SENILE PLAQUES; CORTICAL HUBS; PET; MODEL; CEREBELLUM; HYPOTHESIS; DIAGNOSIS;

D O I：

10.1002/hbm.22213

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The purpose of this study was to investigate the association between functional connectivity and beta-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN. Hum Brain Mapp 35:779-791, 2014. (c) 2012 Wiley Periodicals, Inc.

引用

页码：779 / 791

页数：13

共 45 条

[1]

Beckmann C.F., 2009, Neuroimage, V47, pS39, DOI [10.1016/S1053-8119(09)71511-3, DOI 10.1016/S1053-8119(09)71511-3]

[2]

Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment [J].

Binnewijzend, Maja A. A. ;

Schoonheim, Menno M. ;

Sanz-Arigita, Ernesto ;

Wink, Alle Meije ;

van der Flier, Wiesje M. ;

Tolboom, Nelleke ;

Adriaanse, Sofie M. ;

Damoiseaux, Jessica S. ;

Scheltens, Philip ;

van Berckel, Bart N. M. ;

Barkhof, Frederik .

NEUROBIOLOGY OF AGING, 2012, 33 (09) :2018-2028

[3]

FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI [J].

BISWAL, B ;

YETKIN, FZ ;

HAUGHTON, VM ;

HYDE, JS .

MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) :537-541

[4]

Toward discovery science of human brain function [J].

Biswal, Bharat B. ;

Mennes, Maarten ;

Zuo, Xi-Nian ;

Gohel, Suril ;

Kelly, Clare ;

Smith, Steve M. ;

Beckmann, Christian F. ;

Adelstein, Jonathan S. ;

Buckner, Randy L. ;

Colcombe, Stan ;

Dogonowski, Anne-Marie ;

Ernst, Monique ;

Fair, Damien ;

Hampson, Michelle ;

Hoptman, Matthew J. ;

Hyde, James S. ;

Kiviniemi, Vesa J. ;

Kotter, Rolf ;

Li, Shi-Jiang ;

Lin, Ching-Po ;

Lowe, Mark J. ;

Mackay, Clare ;

Madden, David J. ;

Madsen, Kristoffer H. ;

Margulies, Daniel S. ;

Mayberg, Helen S. ;

McMahon, Katie ;

Monk, Christopher S. ;

Mostofsky, Stewart H. ;

Nagel, Bonnie J. ;

Pekar, James J. ;

Peltier, Scott J. ;

Petersen, Steven E. ;

Riedl, Valentin ;

Rombouts, Serge A. R. B. ;

Rypma, Bart ;

Schlaggar, Bradley L. ;

Schmidt, Sein ;

Seidler, Rachael D. ;

Siegle, Greg J. ;

Sorg, Christian ;

Teng, Gao-Jun ;

Veijola, Juha ;

Villringer, Arno ;

Walter, Martin ;

Wang, Lihong ;

Weng, Xu-Chu ;

Whitfield-Gabrieli, Susan ;

Williamson, Peter ;

Windischberger, Christian .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (10) :4734-4739

[5]

Boellaard R, 2001, J NUCL MED, V42, P808

[6]

Brix G, 1997, J NUCL MED, V38, P1614

[7]

Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease [J].

Buckner, Randy L. ;

Sepulcre, Jorge ;

Talukdar, Tanveer ;

Krienen, Fenna M. ;

Liu, Hesheng ;

Hedden, Trey ;

Andrews-Hanna, Jessica R. ;

Sperling, Reisa A. ;

Johnson, Keith A. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (06) :1860-1873

[8]

Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory [J].

Buckner, RL ;

Snyder, AZ ;

Shannon, BJ ;

LaRossa, G ;

Sachs, R ;

Fotenos, AF ;

Sheline, YI ;

Klunk, WE ;

Mathis, CA ;

Morris, JC ;

Mintun, MA .

JOURNAL OF NEUROSCIENCE, 2005, 25 (34) :7709-7717

[9]

A method for making group inferences from functional MRI data using independent component analysis [J].

Calhoun, VD ;

Adali, T ;

Pearlson, GD ;

Pekar, JJ .

HUMAN BRAIN MAPPING, 2001, 14 (03) :140-151

[10]

Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo [J].

Cirrito, John R. ;

Kang, Jae-Eun ;

Lee, Jiyeon ;

Stewart, Floy R. ;

Verges, Deborah K. ;

Silverio, Luz M. ;

Bu, Guojun ;

Mennerick, Steven ;

Holtzman, David M. .

NEURON, 2008, 58 (01) :42-51

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