New treatment regimes for virus-induced exacerbations of asthma

被引：22

作者：

Edwards, Michael R.

Kebadze, Tatiana

Johnson, Malcolm W.

Johnston, Sebastian L.

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Resp Med, Wright Fleming Inst Infect & Immun, Natl Heart Lung Inst, London, England

[2] GlaxoSmithKline, Greenford, Middx, England

来源：

PULMONARY PHARMACOLOGY & THERAPEUTICS | 2006年 / 19卷 / 05期

关键词：

rhinovirus; asthma; therapy; NF-kappa B; lung; steroid; interferon;

D O I：

10.1016/j.pupt.2005.09.005

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

This review will focus on the role of viruses as causes of asthma exacerbations. The article will briefly review the current literature supporting this view, with a special focus on human rhinovirus (RV), the main virus associated with exacerbations of asthma. The review will then refer to possible strategies for treatment, and will include discussion on treatment with specific anti-viral therapy and type I interferon as a treatment for RV. The review will also include a discussion on current therapies for asthma, such as glucocorticosteroid and beta(2) agonist therapy alone and in combination and why this may be relevant to virus-induced exacerbations of asthma. Finally, the potential for future anti-inflammatory/immunomodulatory therapies with a focus on NF-KB inhibition will be discussed. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：320 / 334

页数：15

相关论文

共 176 条

[1]

Adcock I M, 2000, Monaldi Arch Chest Dis, V55, P256

[2]

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[3]

SUPPRESSION OF COLDS IN HUMAN VOLUNTEERS CHALLENGED WITH RHINOVIRUS BY A NEW SYNTHETIC DRUG (R61837) [J].

ALNAKIB, W ;

HIGGINS, PG ;

BARROW, GI ;

TYRRELL, DAJ ;

ANDRIES, K ;

VANDENBUSSCHE, G ;

TAYLOR, N ;

JANSSEN, PAJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (04) :522-525

[4]

Anti-inflammatory, membrane-stabilizing interactions of salmeterol with human neutrophils in vitro [J].

Anderson, R ;

Feldman, C ;

Theron, AJ ;

Ramafi, G ;

Cole, PJ ;

Wilson, R .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 (07) :1387-1394

[5]

INVITRO STUDIES OF THE ANTIRHINOVIRUS ACTIVITY OF SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 [J].

ARRUDA, E ;

CRUMP, CE ;

MARLIN, SD ;

MERLUZZI, VJ ;

HAYDEN, FG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (06) :1186-1191

[6]

Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection [J].

Balachandran, S ;

Roberts, PC ;

Brown, LE ;

Truong, H ;

Pattnaik, AK ;

Archer, DR ;

Barber, GN .

IMMUNITY, 2000, 13 (01) :129-141

[7]

DETECTION OF RHINOVIRUS INFECTION OF THE NASAL-MUCOSA BY OLIGONUCLEOTIDE IN-SITU HYBRIDIZATION [J].

BARDIN, PG ;

JOHNSTON, SL ;

SANDERSON, G ;

ROBINSON, BS ;

PICKETT, MA ;

FRAENKEL, DJ ;

HOLGATE, ST .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1994, 10 (02) :207-213

[8]

NF-kappa B: A pivotal role in asthma and a new target for therapy [J].

Barnes, PJ ;

Adcock, IM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (02) :46-50

[9]

The x-ray crystal structure of the NF-κB p50•p65 heterodimer bound to the interferon β-κB site [J].

Berkowitz, B ;

Huang, DB ;

Chen-Park, FE ;

Sigler, PB ;

Ghosh, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) :24694-24700

[10]

Transcriptional induction of multiple cytokines by human respiratory syncytial virus requires activation of NF-kappa B and is inhibited by sodium salicylate and aspirin [J].

Bitko, V ;

Velazquez, A ;

Yang, L ;

Yang, YC ;

Barik, S .

VIROLOGY, 1997, 232 (02) :369-378

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