Positive association between synapsin II and schizophrenia

被引:48
作者
Chen, Q
He, G
Wang, XY
Chen, QY
Liu, XM
Gu, ZZ
Liu, J
Li, KQ
Wang, SJ
Zhu, SM
Feng, GY
He, L
机构
[1] Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, Shanghai 200030, Peoples R China
[2] Inst Nutrit Sci, Shanghai, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China
[4] Shanghai Inst Mental Hlth, Shanghai, Peoples R China
[5] Huzhou Third People Hosp, Zhejiang, Peoples R China
[6] Hebei Inst Mental Hlth, Hebei, Peoples R China
[7] Fuyang Mental Hosp, Anhui, Peoples R China
[8] Jilin Inst Mental Hlth, Jilin, Peoples R China
基金
中国国家自然科学基金;
关键词
synapsin II; association; schizophrenia; haplotype; case-control study; single nucleotide polymorphism;
D O I
10.1016/j.biopsych.2004.05.010
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Background: Synapsin II encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. The expressions of messenger ribonucleic acid and protein of synapsin II have been reported to be significantly reduced in the brains of schizophrenia patients. The synapsin II gene is located on 3p25, a region that has been implicated to be associated with schizophrenia by genetic linkage. All these findings suggest synapsin II as a candidate gene for schizophrenia. Methods: In this work, we studied four markers (two single nucleotide polymorphisms (SNPs): rs308963 and rs795009; and two insenion/deletion polymorphisms: rs2307981 and rs2308169) covering 144.2 kilobase pairs (kb) with an average interval of 38 kb in synapsin II in a sample of 654 schizophrenic patients and 628 normal control subjects to explore the mechanism underlying schizophrenia. Results. We found significant differences in allele frequency distribution of SNP rs795009 (p = .000018, odds ratio 1.405, 95916 confidence interval 1.202-1.641) between patients and control subjects. The T allele was significantly higher inpatients than in control subjects. Moreover, the overall frequency of haplotype showed significant differences between patients and control subjects (p < .000001). Conclusions: This study suggests a positive association between synaspin II and schizophrenia, implying that synapsin II is involved in the etiology of schizophrenia.
引用
收藏
页码:177 / 181
页数:5
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