Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents

被引：37

作者：

Cheng, Xian-Chao ^{[1
]}

Liu, Xin-Yong ^{[1
]}

Xu, Wen-Fang ^{[1
]}

Guo, Xiu-Li ^{[2
]}

Zhang, Ning ^{[2
]}

Song, Yu-Ning ^{[2
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Peoples R China

[2] Shandong Univ, Sch Pharmaceut Sci, Dept Pharmacol, Jinan 250012, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 08期

关键词：

Ligustrazine; Ligustrazine derivatives; Synthesis; Cerebro-cardiac vascular activity; ENDOTHELIAL-CELL; TETRAMETHYLPYRAZINE; CHANNEL;

D O I：

10.1016/j.bmc.2009.03.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel acylpiperazinyl Ligustrazine derivatives was designed, synthesized, and their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities were evaluated. The results showed that compound E33 displayed most potential protective effects on the ECV-304 cells damaged by hydrogen peroxide, and compound E1 was found to be the most active antiplatelet aggregation agent. Structure-activity relationships were briefly discussed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3018 / 3024

页数：7

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