CONNECTIVE TISSUE DISEASES The conundrum of B cell depletion in SLE

被引：15

作者：

Sanz, Inaki ^{[1
]}

机构：

[1] Univ Rochester, Div Clin Immunol & Rheumatol, Med Ctr, Rochester, NY 14642 USA

来源：

NATURE REVIEWS RHEUMATOLOGY | 2009年 / 5卷 / 06期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; NEPHRITIS; RITUXIMAB; THERAPIES; TROUBLES; WORKING; TRIALS;

D O I：

10.1038/nrrheum.2009.100

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Two consecutive trials of rituximab, a B-cell-depleting anti-CD20 monoclonal antibody, have threatened the future of B-cell-targeted therapy for systemic lupus erythematosus (SLE). While rumors of the demise of this approach might be greatly exaggerated, the outcomes of these studies should force academics and the pharmaceutical industry back to the drawing board.

引用

页码：304 / 305

页数：2

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