The NorR protein of Escherichia coli activates expression of the flavorubredoxin gene norV in response to reactive nitrogen species

被引：100

作者：

Hutchings, MI ^{[1
]}

Mandhana, N ^{[1
]}

Spiro, S ^{[1
]}

机构：

[1] Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England

来源：

JOURNAL OF BACTERIOLOGY | 2002年 / 184卷 / 16期

关键词：

D O I：

10.1128/JB.184.16.4640-4643.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Escherichia coli norVW genes encode a flavorubredoxin and NADH:(flavo)rubredoxin reductase, respectively, which are involved in nitric oxide detoxification under anaerobic growth conditions. Here it is shown that the norVW genes also have a role in protection against reactive nitrogen intermediates generated from nitroprusside. Transcription from the norV promoter is activated by the presence of nitroprusside in the growth medium; activation requires the product of a divergently transcribed regulatory gene, norR.

引用

页码：4640 / 4643

页数：4

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