Discriminating among the discriminator bases of tRNAs

被引：29

作者：

Hou, YM

机构：

[1] Dept. Biochem. and Molec. Pharmacol., Thomas Jefferson University, Philadelphia, PA 19107

来源：

CHEMISTRY & BIOLOGY | 1997年 / 4卷 / 02期

关键词：

D O I：

10.1016/S1074-5521(97)90252-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aminoacyl-tRNA synthetases must select their specific tRNAs from the 20 structurally similar tRNAs present in a cell. The discriminator base, at position 73 of the tRNA, is important for this selection but its effects on aminoacylation are variable depending on context, Recent structural studies provide insight into this variability.

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页码：93 / 96

页数：4

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