Protein phosphatase 2A: a panoply of enzymes

被引:281
作者
Virshup, DM
机构
[1] Univ Utah, Sch Med 5C334, Dept Pediat, Salt Lake City, UT 84132 USA
[2] Univ Utah, Sch Med 5C334, Dept Oncol Sci, Salt Lake City, UT 84132 USA
关键词
D O I
10.1016/S0955-0674(99)00074-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Protein phosphatase 2A describes an extended family of intracellular protein serine/threonine phosphatases sharing a common catalytic subunit that regulates a variety of processes by means of diverse regulatory subunits. During the past year, studies have shown that protein phosphatase 2A influences events ranging from the initiation of DNA replication to vertebrate axis formation to apoptosis.
引用
收藏
页码:180 / 185
页数:6
相关论文
共 53 条
[1]   Expression of I2PP2A, inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity [J].
Al-Murrani, SWK ;
Woodgett, JR ;
Damuni, Z .
BIOCHEMICAL JOURNAL, 1999, 341 :293-298
[2]  
Baharians Z, 1999, MOL CARCINOGEN, V24, P246, DOI 10.1002/(SICI)1098-2744(199904)24:4<246::AID-MC2>3.0.CO
[3]  
2-H
[4]   Wnt signaling: why is everything so negative? [J].
Brown, JD ;
Moon, RT .
CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (02) :182-187
[5]   Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Bα subunit [J].
Bryant, JC ;
Westphal, RS ;
Wadzinski, BE .
BIOCHEMICAL JOURNAL, 1999, 339 :241-246
[6]   Absence of PPP2R1B gene alterations in primary ovarian cancers [J].
Campbell, IG ;
Manolitsas, T .
ONCOGENE, 1999, 18 (46) :6367-6369
[7]   DIFFERENT OLIGOMERIC FORMS OF PROTEIN PHOSPHATASE-2A ACTIVATE AND INHIBIT SIMIAN-VIRUS 40 DNA-REPLICATION [J].
CEGIELSKA, A ;
SHAFFER, S ;
DERUA, R ;
GORIS, J ;
VIRSHUP, DM .
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) :4616-4623
[8]   α4 associates with protein phosphatases 2A, 4, and 6 [J].
Chen, J ;
Peterson, RT ;
Schreiber, SL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 247 (03) :827-832
[9]   Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A [J].
Deng, XM ;
Ito, T ;
Carr, B ;
Mumby, M ;
May, WS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (51) :34157-34163
[10]   Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases [J].
DiComo, CJ ;
Arndt, KT .
GENES & DEVELOPMENT, 1996, 10 (15) :1904-1916