A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertension

Background A mutation in the gene for the angiotensin II type 1 (AT(1)) receptor (A(1166)C) has been reported to be associated with primary hypertension. Objective To determine whether this observation could be confirmed with a different population sample. Design We examined 414 individuals with primary hypertension and 172 normotensive controls. Methods The mutation in the gene for the AT(1) receptor was detected using restriction polymerase chain reaction. Conclusions We detected no association of the AT(1) receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the C-1166 allele among hypertensive patients with a late age at diagnosis (> 50 years) was observed.