Cystine/glutamate exchange serves as the source for extracellular glutamate: Modifications by repeated cocaine administration

被引：104

作者：

Baker, DA ^{[1
]}

Shen, H ^{[1
]}

Kalivas, PW ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA

来源：

AMINO ACIDS | 2002年 / 23卷 / 1-3期

关键词：

cocaine; cystine/glutamate exchanger; microdialysis;

D O I：

10.1007/s00726-001-0122-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.

引用

页码：161 / 162

页数：2