Cancer genomics

被引：56

作者：

Weber, BL ^{[1
]}

机构：

[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

来源：

CANCER CELL | 2002年 / 1卷 / 01期

关键词：

D O I：

10.1016/S1535-6108(02)00026-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The draft human genome sequence and the dissemination of high throughput technology provides opportunities for systematic analysis of cancer cells. Genome-wide mutation screens, high resolution analysis of chromosomal abberations and expression profiling all give comprehensive views of genetic alterations in cancer cells. From these analyses will come a complete list of the genetic changes that drive malignant transformation and of the therapeutic targets that may be exploited for clinical benefit.

引用

页码：37 / 47

页数：11

共 56 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] Fractional D-branes and their gauge duals [J].

Bertolini, M ;

Di Vecchia, P ;

Marotta, R ;

Frau, M ;

Lerda, A ;

Pesando, I .

JOURNAL OF HIGH ENERGY PHYSICS, 2001, (02) :XXIV-15

[3] Molecular classification of cutaneous malignant melanoma by gene expression profiling [J].

Bittner, M ;

Meitzer, P ;

Chen, Y ;

Jiang, Y ;

Seftor, E ;

Hendrix, M ;

Radmacher, M ;

Simon, R ;

Yakhini, Z ;

Ben-Dor, A ;

Sampas, N ;

Dougherty, E ;

Wang, E ;

Marincola, F ;

Gooden, C ;

Lueders, J ;

Glatfelter, A ;

Pollock, P ;

Carpten, J ;

Gillanders, E ;

Leja, D ;

Dietrich, K ;

Beaudry, C ;

Berens, M ;

Alberts, D ;

Sondak, V ;

Hayward, N ;

Trent, J .

NATURE, 2000, 406 (6795) :536-540

[4] Oncogenic kinase signalling [J].

Blume-Jensen, P ;

Hunter, T .

NATURE, 2001, 411 (6835) :355-365

[5] Minimum information about a microarray experiment (MIAME) - toward standards for microarray data [J].

Brazma, A ;

Hingamp, P ;

Quackenbush, J ;

Sherlock, G ;

Spellman, P ;

Stoeckert, C ;

Aach, J ;

Ansorge, W ;

Ball, CA ;

Causton, HC ;

Gaasterland, T ;

Glenisson, P ;

Holstege, FCP ;

Kim, IF ;

Markowitz, V ;

Matese, JC ;

Parkinson, H ;

Robinson, A ;

Sarkans, U ;

Schulze-Kremer, S ;

Stewart, J ;

Taylor, R ;

Vilo, J ;

Vingron, M .

NATURE GENETICS, 2001, 29 (04) :365-371

[6]

CLARK SJ, 1994, NUCLEIC ACIDS RES, V22, P2990, DOI 10.1093/nar/22.15.2990

[7] Aberrant CpG-island methylation has non-random and tumour-type-specific patterns [J].

Costello, JF ;

Frühwald, MC ;

Smiraglia, DJ ;

Rush, LJ ;

Robertson, GP ;

Gao, X ;

Wright, FA ;

Feramisco, JD ;

Peltomäki, P ;

Lang, JC ;

Schuller, DE ;

Yu, L ;

Bloomfield, CD ;

Caligiuri, MA ;

Yates, A ;

Nishikawa, R ;

Huang, HJS ;

Petrelli, NJ ;

Zhang, XL ;

O'Dorisio, MS ;

Held, WA ;

Cavenee, WK ;

Plass, C .

NATURE GENETICS, 2000, 24 (02) :132-138

[8] REACTIVITY OF CYTOSINE AND THYMINE IN SINGLE-BASE-PAIR MISMATCHES WITH HYDROXYLAMINE AND OSMIUM-TETROXIDE AND ITS APPLICATION TO THE STUDY OF MUTATIONS [J].

COTTON, RGH ;

RODRIGUES, NR ;

CAMPBELL, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) :4397-4401

[9] Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells [J].

Druker, BJ ;

Tamura, S ;

Buchdunger, E ;

Ohno, S ;

Segal, GM ;

Fanning, S ;

Zimmermann, J ;

Lydon, NB .

NATURE MEDICINE, 1996, 2 (05) :561-566

[10]

Esteller M, 2001, CANCER RES, V61, P3225

← 1 2 3 4 5 6 →