ANGPTL4 in Metabolic and Cardiovascular Disease

被引：233

作者：

Aryal, Binod ^{[1
,2
,3
]}

Price, Nathan L. ^{[1
,2
,3
]}

Suarez, Yajaira ^{[1
,2
,3
,4
]}

Fernandez-Hernando, Carlos ^{[1
,2
,3
,4
]}

机构：

[1] Yale Univ, Sch Med, Vasc Biol & Therapeut Program, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Integrat Cell Signaling & Neurobiol Metab Program, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Dept Comparat Med, New Haven, CT 06520 USA

[4] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2019年 / 25卷 / 08期

基金：

美国国家卫生研究院;

关键词：

ANGIOPOIETIN-LIKE PROTEIN; CORONARY-HEART-DISEASE; IMPROVES GLUCOSE-TOLERANCE; COILED-COIL DOMAIN; LIPOPROTEIN-LIPASE; PLASMA TRIGLYCERIDES; INSULIN-RESISTANCE; INHIBITION; RISK; EXPRESSION;

D O I：

10.1016/j.molmed.2019.05.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Alterations in circulating lipids and ectopic lipid deposition impact on the risk of developing cardiovascular and metabolic diseases. Lipoprotein lipase (LPL) hydrolyzes fatty acids (FAs) from triglyceride (TAG)-rich lipoproteins including very low density lipoproteins (VLDLs) and chylomicrons, and regulates their distribution to peripheral tissues. Angiopoietin-like 4 (ANGPTL4) mediates the inhibition of LPL activity under different circumstances. Accumulating evidence associates ANGPTL4 directly with the risk of atherosclerosis and type 2 diabetes (T2D). This review focuses on recent findings on the role of ANGPTL4 in metabolic and cardiovascular diseases. We highlight human and murine studies that explore ANGPTL4 functions in different tissues and how these effect disease development through possible autocrine and paracrine forms of regulation.

引用

页码：723 / 734

页数：12

共 103 条

[1]

ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels and predicts cardiovascular disease risk in Type 2 diabetic Tunisian population [J].

Abid, Kaouthar ;

Trimeche, Thouraya ;

Mili, Donia ;

Msolli, Mohamed Amine ;

Trabelsi, Imen ;

Nouira, Semir ;

Kenani, Abderraouf .

LIPIDS IN HEALTH AND DISEASE, 2016, 15

[2]

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis [J].

Adachi, Hironori ;

Fujiwara, Yukio ;

Kondo, Tatsuya ;

Nishikawa, Takeshi ;

Ogawa, Rei ;

Matsumura, Takeshi ;

Ishii, Norio ;

Nagai, Ryoji ;

Miyata, Keishi ;

Tabata, Mitsuhisa ;

Motoshima, Hiroyuki ;

Furukawa, Noboru ;

Tsuruzoe, Kaku ;

Kawashima, Junji ;

Takeya, Motohiro ;

Yamashita, Shizuya ;

Koh, Gou Young ;

Nagy, Andras ;

Suda, Toshio ;

Oike, Yuichi ;

Araki, Eiichi .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 379 (04) :806-811

[3]

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis [J].

Aryal, Binod ;

Singh, Abhishek K. ;

Zhang, Xinbo ;

Varela, Luis ;

Rotllan, Noemi ;

Goedeke, Leigh ;

Chaube, Balkrishna ;

Camporez, Joao-Paulo ;

Vatner, Daniel F. ;

Horvath, Tamas L. ;

Shulman, Gerald I. ;

Suarez, Yajaira ;

Fernandez-Hernando, Carlos .

JCI INSIGHT, 2018, 3 (06)

[4]

ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression [J].

Aryal, Binod ;

Rotllan, Noemi ;

Araldi, Elisa ;

Ramirez, Cristina M. ;

He, Shun ;

Chousterman, Benjamin G. ;

Fenn, Ashley M. ;

Wanschel, Amarylis ;

Madrigal-Matute, Julio ;

Warrier, Nikhil ;

Martin-Ventura, Jose L. ;

Swirski, Filip K. ;

Suarez, Yajaira ;

Fernandez-Hernando, Carlos .

NATURE COMMUNICATIONS, 2016, 7

[5]

ANGPTL4 gene E40K variation protects against obesity-associated dyslipidemia in participants with obesity [J].

Bailetti, D. ;

Bertoccini, L. ;

Mancina, R. M. ;

Barchetta, I ;

Capoccia, D. ;

Cossu, E. ;

Pujia, A. ;

Lenzi, A. ;

Leonetti, F. ;

Cavallo, M. G. ;

Romeo, S. ;

Baroni, M. G. .

OBESITY SCIENCE & PRACTICE, 2019, 5 (01) :83-90

[6]

Plasma ANGPTL-4 is Associated with Obesity and Glucose Tolerance: Cross-Sectional and Longitudinal Findings [J].

Barja-Fernandez, Silvia ;

Maria Moreno-Navarrete, Jose ;

Folgueira, Cintia ;

Xifra, Gemma ;

Sabater, Monica ;

Castelao, Cecilia ;

Ferno, Johan ;

Leis, Rosaura ;

Dieguez, Carlos ;

Casanueva, Felipe F. ;

Ricart, Wifredo ;

Seoane, Luisa M. ;

Manuel Fernandez-Real, Jose ;

Nogueiras, Ruben .

MOLECULAR NUTRITION & FOOD RESEARCH, 2018, 62 (10)

[7]

Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients With Very High Triglyceride Levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] Trial) [J].

Bays, Harold E. ;

Ballantyne, Christie M. ;

Kastelein, John J. ;

Isaacsohn, Jonathan L. ;

Braeckman, Rene A. ;

Soni, Paresh N. .

AMERICAN JOURNAL OF CARDIOLOGY, 2011, 108 (05) :682-690

[8]

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons [J].

Beigneux, Anne P. ;

Davies, Brandon S. J. ;

Gin, Peter ;

Weinstein, Michael M. ;

Farber, Emily ;

Qiao, Xin ;

Peale, Franklin ;

Bunting, Stuart ;

Walzem, Rosemary L. ;

Wong, Jinny S. ;

Blaner, William S. ;

Ding, Zhi-Ming ;

Melford, Kristan ;

Wongsiriroj, Nuttaporn ;

Shu, Xiao ;

de Sauvage, Fred ;

Ryan, Robert O. ;

Fong, Loren G. ;

Bensadoun, Andre ;

Young, Stephen G. .

CELL METABOLISM, 2007, 5 (04) :279-291

[9]

Lipoprotein lipase is active as a monomer [J].

Beigneux, Anne P. ;

Allan, Christopher M. ;

Sandoval, Norma P. ;

Cho, Geoffrey W. ;

Heizer, Patrick J. ;

Jung, Rachel S. ;

Stanhope, Kimber L. ;

Havel, Peter J. ;

Birrane, Gabriel ;

Meiyappan, Muthuraman ;

Gill, John E. ;

Murakami, Masami ;

Miyashita, Kazuya ;

Nakajima, Katsuyuki ;

Ploug, Michael ;

Fong, Loren G. ;

Young, Stephen G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (13) :6319-6328

[10]

LIPOPROTEIN-LIPASE ENHANCES THE BINDING OF CHYLOMICRONS TO LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN [J].

BEISIEGEL, U ;

WEBER, W ;

BENGTSSONOLIVECRONA, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) :8342-8346

← 1 2 3 4 5 6 7 8 9 10 →