Efficacy and circulating tumor DNA (ctDNA) analysis of the BRAF inhibitor dabrafenib (D), MEK inhibitor trametinib (T), and anti-EGFR antibody panitumumab (P) in patients (pts) with BRAF V600E-mutated (BRAFm) metastatic colorectal cancer (mCRC)

被引：19

作者：

Corcoran, R. B. ^{[1
]}

Andre, T. ^{[2
]}

Yoshino, T. ^{[3
]}

Bendell, J. C. ^{[4
]}

Atreya, C. E. ^{[5
]}

Schellens, J. H. M. ^{[6
]}

Ducreux, M. P. ^{[7
]}

McRee, A. ^{[8
]}

Siena, S. ^{[9
]}

Middleton, G. ^{[10
]}

Gordon, M. ^{[11
]}

Humblet, Y. ^{[12
]}

Muro, K. ^{[13
]}

Elez, E. ^{[14
]}

Yaeger, R. ^{[15
]}

Sidhu, R. ^{[16
]}

Squires, M. ^{[17
]}

Jaeger, S. ^{[18
]}

Rangwala, F. ^{[19
]}

Van Cutsem, E. ^{[20
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA

[2] Hop St Antoine, Oncol Med, Paris, France

[3] Natl Canc Ctr Hosp East, Gastroenterol & Gastrointestinal Oncol, Chiba, Japan

[4] Sarah Cannon Res Inst, GI Oncol Res, Nashville, TN USA

[5] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

[6] Netherlands Canc Inst, Clin Pharmacol, Amsterdam, Netherlands

[7] Inst Gustave Roussy, Med, Villejuif, France

[8] Univ North Carolina Chapel Hill, GI Med Oncol, Chapel Hill, NC USA

[9] Univ Milan, Niguarda Canc Ctr, Osped Niguarda, Milan, Italy

[10] Univ Birmingham, Sch Canc Sci, Birmingham, W Midlands, England

[11] Pinnacle Oncol Hematol, Div Arizona Ctr Canc Care, Scottsdale, AZ USA

[12] St Luc Univ Hosptial, Dept Med Oncol, Brussels, Belgium

[13] Aichi Canc Ctr Hosp, Dept Clin Oncol, Nagoya, Aichi, Japan

[14] Vall Hebron Univ Hosp, Med Oncol, Barcelona, Spain

[15] Mem Sloan Kettering Canc Ctr, Gastrointestinal Oncol, 1275 York Ave, New York, NY 10021 USA

[16] Amgen Inc, Hematol Oncol, Thousand Oaks, CA 91320 USA

[17] Novartis Pharma AG, Global Oncol, Basel, Switzerland

[18] Novartis Inst Biomed Res Inc, Biomarkers & Diagnost Biometr, Boston, MA USA

[19] Novartis Pharmaceut, Global Oncol, East Rutherford, NJ USA

[20] Univ Hosp Leuven, Digest Oncol, Leuven, Belgium

来源：

ANNALS OF ONCOLOGY | 2016年 / 27卷

关键词：

D O I：

10.1093/annonc/mdw370.4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

455O

引用

页数：1