Linear and nonlinear relationships between neuronal activity, oxygen metabolism, and hemodynamic responses

被引：231

作者：

Sheth, SA ^{[1
]}

Nemoto, M ^{[1
]}

Guiou, M ^{[1
]}

Walker, M ^{[1
]}

Pouratian, N ^{[1
]}

Toga, AW ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Lab Neuro Imaging, Los Angeles, CA 90024 USA

来源：

NEURON | 2004年 / 42卷 / 02期

关键词：

D O I：

10.1016/S0896-6273(04)00221-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the relationship between neuronal activity, oxygen metabolism, and hemodynamic responses in rat somatosensory cortex with simultaneous optical intrinsic signal imaging and spectroscopy, laser Doppler flowmetry, and local field potential recordings. Changes in cerebral oxygen consumption increased linearly with synaptic activity but with a threshold effect consistent with the existence of a tissue oxygen buffer. Modeling analysis demonstrated that the coupling between neuronal activity and hemodynamic response magnitude may appear linear over a narrow range but incorporates nonlinear effects that are better described by a threshold or power law relationship. These results indicate that caution is required in the interpretation of perfusion-based indicators of brain activity, such as functional magnetic resonance imaging (fMRI), and may help to refine quantitative models of neurovascular coupling.

引用

页码：347 / 355

页数：9

共 49 条

[1] The neural basis of functional brain imaging signals [J].