Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

被引：2480

作者：

Sonenberg, Nahum ^{[1
,2
]}

Hinnebusch, Alan G. ^{[3
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Goodman Canc Ctr, Montreal, PQ H3G 1Y6, Canada

[3] NICHHD, Lab Gene Regulat & Dev, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2009年 / 136卷 / 04期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

MESSENGER-RNA TRANSLATION; CAP-INDEPENDENT TRANSLATION; TERM SYNAPTIC PLASTICITY; DIET-INDUCED OBESITY; RIBOSOMAL-SUBUNIT; BINDING-PROTEIN; LIFE-SPAN; PREINITIATION COMPLEX; DEPENDENT TRANSLATION; DROSOPHILA CUP;

D O I：

10.1016/j.cell.2009.01.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Translational control in eukaryotic cells is critical for gene regulation during nutrient deprivation and stress, development and differentiation, nervous system function, aging, and disease. We describe recent advances in our understanding of the molecular structures and biochemical functions of the translation initiation machinery and summarize key strategies that mediate general or gene-specific translational control, particularly in mammalian systems.

引用

页码：731 / 745

页数：15

共 143 条

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