Resolution of AIDS-related Castleman's disease with anti-CD20 monoclonal antibodies is associated with declining IL-6 and TNF-α levels

被引：26

作者：

Newsom-Davis, T

Bower, M

Wildfire, A

Thirlwell, C

Nelson, M

Gazzard, B

Stebbing, J

机构：

[1] Chelsea & Westminster Hosp, Dept Oncol, London SW10 9NH, England

[2] Chelsea & Westminster Hosp, Dept HIV Med, London SW10 9NH, England

[3] Chelsea & Westminster Hosp, Imperial Coll Sci Technol & Med, Fac Med, Dept Immunol,Div Invest Sci, London SW10 9NH, England

来源：

LEUKEMIA & LYMPHOMA | 2004年 / 45卷 / 09期

关键词：

AIDS; Castleman's disease; cytokines; HIV; rituximab;

D O I：

10.1080/10428190410001693533

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 32-year-old HIV-1 positive man was diagnosed with Castleman's disease following a long history of constitutional symptoms. Primary therapy with single agent rituximab was associated with a near complete response. During this time, his KSHV (Kaposi's sarcoma-associated herpesvirus) viral load decreased and we also observed immediate, large and sustained decreases in interleukin-6 (IL-6) and tumor necrosis factor-alpha levels (TNF-alpha). This highlights the close association between circulating cytokines such as IL-6 and virally-induced malignancy.

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收藏

页码：1939 / 1941

页数：3

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