Bicyclization of dienes, enynes, and diynes with Ti(II) reagent. New developments towards asymmetric synthesis

被引：61

作者：

Sato, F ^{[1
]}

Urabe, H ^{[1
]}

Okamoto, S ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Kanagawa 2268501, Japan

来源：

PURE AND APPLIED CHEMISTRY | 1999年 / 71卷 / 08期

关键词：

D O I：

10.1351/pac199971081511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The title bis-unsaturated compounds undergo bicyclization with (eta(2)-propene)Ti(O-i-Pr)(2) to give dialkoxytitanacycles, the characteristic reactions of which are highlighted. Substrate-controlled asymmetric cyclizations starting from optically active allenes, enynes having a chiral acetal as a leaving group, and optically active enynoates were found promising to give cyclic compounds with high enantiopurity.

引用

页码：1511 / 1519

页数：9

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