Focal adhesion regulation of cell behavior

被引：791

作者：

Wozniak, MA ^{[1
]}

Modzelewska, K ^{[1
]}

Kwong, L ^{[1
]}

Keely, PJ ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Pharmacol, Madison, WI 53706 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1692卷 / 2-3期

关键词：

focal adhesion; focal adhesion kinase; integrin; Stc; 3D matrix; cell migration; tubulogenesis;

D O I：

10.1016/j.bbamcr.2004.04.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin cytoskeleton. Cells modify focal adhesions in response to changes in the molecular composition, two-dimensional (2D) vs. three-dimensional (3D) structure, and physical forces present in their extracellular matrix environment. We consider here how cells use focal adhesions to regulate signaling complexes and integrin function. Furthermore, we examine how this regulation controls complex cellular behaviors in response to matrices of diverse physical and biochemical properties. One event regulated by the physical structure of the ECM is phosphorylation of focal adhesion kinase (FAK) at Y397, which couples FAK to several signaling pathways that regulate cell proliferation, survival, migration, and invasion. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：103 / 119

页数：17

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