Diffusion-Weighted MR Imaging of Benign and Malignant Breast Lesions Before and After Contrast Enhancement

被引：33

作者：

Janka, R. ^{[1
]}

Hammon, M. ^{[1
]}

Geppert, C. ^{[2
]}

Nothhelfer, A. ^{[1
]}

Uder, M. ^{[1
]}

Wenkel, E. ^{[1
]}

机构：

[1] Univ Hosp Erlangen, Dept Radiol, Erlangen, Germany

[2] Siemens AG, Healthcare Sect, Erlangen, Germany

来源：

ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN | 2014年 / 186卷 / 02期

关键词：

breast; diffusion-weighted MRimaging; contrast media; INTRAVENOUS GADOLINIUM-DTPA; POSITIVE PREDICTIVE-VALUE; COEFFICIENT ADC; CANCER; TUMORS; MAMMOGRAPHY; SIZE; DIFFERENTIATION; SPECIFICITY; CARCINOMA;

D O I：

10.1055/s-0033-1350298

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Purpose: Many publications describe the use of diffusion-weighted imaging (DWI) in breast MRI. This article addresses the question of when to apply the DWI sequence in the course of the scan protocol. The effect of T1-shortening contrast media (CM) on the ADC values of breast lesions is investigated. Materials and Methods: Data were acquired on a 1.5T scanner. 60 patients with 79 lesions (20 benign, 59 malignant) were included. The DWI sequence (4mm slice thickness, b-values: 50, 400, 800) was applied before and after CM administration. Before calculating the ADC map, the b50, b400 and b800 series were analyzed concerning lesion displacement. ADC values before and after CM application were compared. Results: The mean lesion size was 1.50.8cm. On the basis of the b50 and b400 measurements, the mean ADC value of benign lesions was 1.89 0.30x10(-3)mm(2)/s before and 1.850.28x10(-3) mm(2)/s after CM administration. The consecutive values for two pure mucinous carcinomas were 1.88x10(-3)mm(2)/s and 1.81x10(3)mm(2)/s and for the remaining malignant lesions 1.000.18x10(-3) mm(2)/s and 0.880.21x10(-3)mm(2). On the basis of the b50, b400 and b800 measurements, the mean ADC value of benign lesions was 1.99 0.37x10(-3)mm(2)/s before and 1.970.30x10(-3)mm(2)/s after CM application, whereas the mean ADC value of the malignant lesions was 0.90 +/- 0.14x10(-3)mm(2)/s before and 0.80 +/- 0.14x10(-3)mm(2)/s after CM application. While there was no significant change for benign lesions, the ADC value decrease in post-contrast malignant lesions was highly significant. Conclusion: DWI after CM is possible and even leads to slightly better lesion discrimination between benign and malignant. However, further studies need to be performed to verify this. Citation Format: center dot Janka R, Hammon M, Geppert C etal. Diffusion-Weighted MR Imaging of Benign and Malignant Breast Lesions Before and After Contrast Enhancement. Fortschr Rontgenstr 2014; 186: 130-135

引用

页码：130 / 135

页数：6

共 32 条

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[2]

Sensitivity and specificity of unenhanced MR mammography (DWI combined with T2-weighted TSE imaging, ueMRM) for the differentiation of mass lesions [J].