The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition

被引：127

作者：

Crowe, Francesca L. ^{[1
]}

Key, Timothy J. ^{[1
]}

Allen, Naomi E. ^{[1
]}

Appleby, Paul N. ^{[1
]}

Roddam, Andrew ^{[1
]}

Overvad, Kim ^{[2
]}

Gronbaek, Henning ^{[3
]}

Tjonneland, Anne ^{[4
]}

Halkjaer, Jutte ^{[4
]}

Dossus, Laure ^{[5
]}

Boeing, Heiner ^{[6
]}

Kroeger, Janine ^{[6
]}

Trichopoulou, Antonia ^{[7
]}

Dilis, Vardis ^{[7
]}

Trichopoulos, Dimitrios ^{[8
,9
]}

Boutron-Ruault, Marie-Christine ^{[10
]}

De Lauzon, Blandine ^{[10
]}

Clavel-Chapelon, Francoise ^{[10
]}

Palli, Domenico ^{[11
]}

Berrino, Franco ^{[12
]}

Panico, Salvatore ^{[13
]}

Tumino, Rosario ^{[14
]}

Sacerdote, Carlotta ^{[15
]}

Bueno-de-Mesquita, H. Bas ^{[16
]}

Vrieling, Alina ^{[16
]}

van Gils, Carla H. ^{[17
]}

Peeters, Petra H. M. ^{[17
,18
]}

Gram, Inger T. ^{[19
]}

Skeie, Guri ^{[19
]}

Lund, Eiliv ^{[19
]}

Rodriguez, Laudina ^{[20
]}

Jakszyn, Paula ^{[21
]}

Molina-Montes, Esther ^{[22
]}

Tormo, Maria J. ^{[23
]}

Barricarte, Aurelio ^{[24
]}

Larranaga, Nerea ^{[25
]}

Khaw, Kay-Tee ^{[26
]}

Bingham, Sheila ^{[27
,28
]}

Rinaldi, Sabina ^{[29
]}

Slimani, Nadia ^{[29
]}

Norat, Teresa ^{[18
]}

Gallo, Valentina ^{[18
]}

Riboli, Elio ^{[18
]}

Kaaks, Rudolf ^{[5
]}

机构：

[1] Univ Oxford, Canc Epidemiol Unit, Oxford OX3 7LF, England

[2] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[3] Aarhus Univ Hosp, Aarhus Med Dept 5, Aalborg, Denmark

[4] Inst Canc Epidemiol Strandboulevarden, Danish Canc Soc, Copenhagen, Denmark

[5] German Canc Res Ctr, Div Clin Epidemiol, Heidelberg, Germany

[6] German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany

[7] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-11527 Athens, Greece

[8] Hellen Hlth Fdn, Athens, Greece

[9] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[10] Inst Gustave Roussy, INSERM, F-94805 Villejuif, France

[11] ISPO Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[12] Ist Nazl Tumori, Fdn IRCCS, Etiol Epidemiol & Prevent Unit, I-20133 Milan, Italy

[13] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[14] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy

[15] Epidemiol & Prevenz Oncol CPO Piemonte, Turin, Italy

[16] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[17] Julius Ctr Univ, Med Ctr, Utrecht, Netherlands

[18] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Epidemiol & Publ Hlth, London, England

[19] Univ Tromso, Inst Community Med, Tromso, Norway

[20] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[21] ICO, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[22] Andalusian Sch Publ Hlth, Granada, Spain

[23] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[24] Publ Hlth Inst Navarra, Pamplona, Spain

[25] Basque Govt, Publ Hlth Dept Gipuzkoa, Madrid, Spain

[26] Univ Cambridge, Sch Clin Med, Dept Publ Hlth & Primary Care, Inst Publ Hlth, Cambridge, England

[27] Univ Cambridge, MRC, Dunn Human Nutr Unit, Cambridge, England

[28] Univ Cambridge, MRC, Ctr Nutr Epidemiol Canc Prevent & Survival, Dept Publ Hlth & Primary Care, Cambridge, England

[29] IARC WHO, Lyon, France

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2009年 / 18卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

GROWTH-FACTOR-I; FACTOR BINDING PROTEIN-3; LIFE-STYLE FACTORS; FACTOR (IGF)-I; CIRCULATING LEVELS; BONE TURNOVER; MILK INTAKE; C-PEPTIDE; INSULIN; RISK;

D O I：

10.1158/1055-9965.EPI-08-0781

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each I SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1333-40)

引用

页码：1333 / 1340

页数：8

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