Use of the surgical wound infection model to determine the efficacious dosing regimen of retapamulin, a novel topical antibiotic

被引：37

作者：

Rittenhouse, Stephen ^{[1
]}

Singley, Christine ^{[1
]}

Hoover, Jennifer ^{[1
]}

Page, Roni ^{[1
]}

Payne, David ^{[1
]}

机构：

[1] GlaxoSmith Pharmaceut, Dept Microbiol, MMPD, CEDD, Upper Providence, PA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 11期

关键词：

STAPHYLOCOCCUS-AUREUS; FUSIDIC ACID; MUPIROCIN RESISTANCE; SURVEILLANCE; AGENTS;

D O I：

10.1128/AAC.00183-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effect of topically applied retapamulin ointment was evaluated using various dosing regimens in the Staphylococcus aureus and Streptococcus pyogenes wound infection model. Retapamulin (1%, wt/wt) was efficacious using twice-daily (b.i.d.) applications for 4 or 5 days. These data underpinned the decision to evaluate 1% retapamulin b.i.d. in clinical trials.

引用

页码：3886 / 3888

页数：3

共 12 条

[1]

[Anonymous], 2006, METH DIL ANT SUSC TE, Vseventh

[2] Comparative efficacy of gemifloxacin in experimental models of pyelonephritis and wound infection [J].

Barry, V ;

Page, R ;

Satterfield, J ;

Singley, C ;

Straub, R ;

Woodnutt, G .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 :87-93

[3] EFFICACY OF TOPICAL MUPIROCIN AGAINST AN EXPERIMENTAL STAPHYLOCOCCUS-AUREUS SURGICAL WOUND-INFECTION [J].

BOON, RJ ;

BEALE, AS ;

SUTHERLAND, R .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1985, 16 (04) :519-526

[4] RESPONSE OF STREPTOCOCCUS-PYOGENES TO THERAPY WITH AMOXICILLIN OR AMOXICILLIN-CLAVULANIC ACID IN A MOUSE MODEL OF MIXED INFECTION CAUSED BY STAPHYLOCOCCUS-AUREUS AND STREPTOCOCCUS-PYOGENES [J].

BOON, RJ ;

BEALE, AS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (08) :1204-1209

[5] Fusidic acid in vitro activity [J].

Collignon, P ;

Turnidge, J .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 1999, 12 :S45-S58

[6] Emerging elevated mupirocin resistance rates among staphylococcal isolates in the SENTRY Antimicrobial Surveillance Program (2000): correlations of results from disk diffusion, Etest and reference dilution methods [J].

Deshpande, LM ;

Fix, AM ;

Pfaller, MA ;

Jones, RN .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2002, 42 (04) :283-290

[7] Fusidic acid resistance in Staphylococcus aureus [J].

Dobie, D ;

Gray, J .

ARCHIVES OF DISEASE IN CHILDHOOD, 2004, 89 (01) :74-77

[8] Efficacy of a new cream formulation of mupirocin: Comparison with oral and topical agents in experimental skin infections [J].

Gisby, J ;

Bryant, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (02) :255-260

[9] Prevalence of mupirocin resistance in clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis:: Results of the Antimicrobial Resistance Surveillance Study of the Paul-Ehrlich-Society for Chemotherapy, 2001 [J].

Kresken, M ;

Hafner, D ;

Schmitz, FJ ;

Wichelhaus, TA .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2004, 23 (06) :577-581

[10] CHARACTERIZATION AND QUANTITATION OF EXPERIMENTAL SURGICAL WOUND INFECTIONS USED TO EVALUATE TOPICAL ANTIBACTERIAL AGENTS [J].

MCRIPLEY, RJ ;

WHITNEY, RR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (01) :38-44

← 1 2 →