Novel coumarin derivatives with expected biological activity

被引：208

作者：

Nofal, ZM ^{[1
]}

El-Zahar, MI ^{[1
]}

El-Karim, SSA ^{[1
]}

机构：

[1] Natl Res Ctr, Therapeut Chem Dept, Cairo, Egypt

来源：

MOLECULES | 2000年 / 5卷 / 02期

关键词：

substituted coumarins; nitro reduction; benzylidinyl amino coumarins;

D O I：

10.3390/50200099

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of novel 3-bromo-4-methyl-7-methoxy-8-amino substituted coumarins and 2-substituted 7-bromo-6-methyl-8H-pyrano-benzimidazo les, benzoxazoles and/or benzoxazine-8-ones were synthesized for the purpose of pharmacological evaluation. Some representative compounds showed antitumor activity in vitro on Ehrlich ascites carcinoma in the preliminary testing.

引用

页码：99 / 113

页数：15

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