GABA release in the dorsal raphe nucleus: Role in the control of REM sleep

被引:168
作者
Nitz, D
Siegel, J
机构
[1] VET AFFAIRS MED CTR, SEPULVEDA, CA 91343 USA
[2] UNIV CALIF LOS ANGELES, DEPT NEUROSCI, LOS ANGELES, CA 90024 USA
[3] UNIV CALIF LOS ANGELES, DEPT PSYCHIAT, LOS ANGELES, CA 90024 USA
关键词
microdialysis; muscimol; picrotoxin; serotonin;
D O I
10.1152/ajpregu.1997.273.1.R451
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The cessation of firing of serotonergic dorsal raphe neurons is a key controlling event of rapid eye movement (REM) sleep. We tested the hypothesis that this cessation of activity is due to gamma-aminobutyric acid (GABA) release using the in vivo microdialysis technique. We found that REM sleep is accompanied by a selective increase in GABA release, but not by a change in glutamate or glycine release in the dorsal raphe nucleus. Microinjection of the GABA agonist muscimol into the dorsal raphe increased REM sleep, although microperfusion of the GABA antagonist picrotoxin blocked REM sleep. These results implicate GABA release as a critical element in the production of the REM sleep state and in the control of discharge in serotonergic neurons across the sleep/wake cycle.
引用
收藏
页码:R451 / R455
页数:5
相关论文
共 45 条
[1]   SEROTONERGIC AND NON-SEROTONERGIC NEURONS OF DORSAL RAPHE - RECIPROCAL CHANGES IN FIRING INDUCED BY PERIPHERAL-NERVE STIMULATION [J].
AGHAJANIAN, GK ;
WANG, RY ;
BARABAN, J .
BRAIN RESEARCH, 1978, 153 (01) :169-175
[2]   INTRACELLULAR-RECORDINGS FROM SEROTONERGIC DORSAL RAPHE NEURONS - PACEMAKER POTENTIALS AND THE EFFECT OF LSD [J].
AGHAJANIAN, GK ;
VANDERMAELEN, CP .
BRAIN RESEARCH, 1982, 238 (02) :463-469
[3]   AUTORADIOGRAPHIC ANALYSIS OF DIFFERENTIAL ASCENDING PROJECTIONS OF DORSAL AND MEDIAN RAPHE NUCLEI IN RAT [J].
AZMITIA, EC ;
SEGAL, M .
JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 179 (03) :641-667
[4]   GABA-ACCUMULATING NEURONS IN THE NUCLEUS RAPHE DORSALIS AND PERIAQUEDUCTAL GRAY IN THE RAT - BIOCHEMICAL AND AUTORADIOGRAPHIC STUDY [J].
BELIN, MF ;
AGUERA, M ;
TAPPAZ, M ;
MCRAEDEGUEURCE, A ;
BOBILLIER, P ;
PUJOL, JF .
BRAIN RESEARCH, 1979, 170 (02) :279-297
[5]   REM-SLEEP PROPENSITY ACCUMULATES DURING 2-H REM-SLEEP DEPRIVATION IN THE REST PERIOD IN RATS [J].
BENINGTON, JH ;
WOUDENBERG, MC ;
HELLER, HC .
NEUROSCIENCE LETTERS, 1994, 180 (01) :76-80
[6]  
CESPUGLIO R, 1979, ELECTROENCEPHALOGR C, V3, P221
[7]  
CHASE MH, 1989, PRINCIPLES PRACTICE, P74
[8]  
DELORME F, 1966, CR SOC BIOL, V160, P2347
[9]  
FORNAL CA, 1994, J PHARMACOL EXP THER, V270, P1345
[10]  
FORT P, 1993, NEUROREPORT, V4, P1123