Neurod1 is essential for the survival and maturation of adult-born neurons

被引：371

作者：

Gao, Zhengliang ^{[1
,2
]}

Ure, Kerstin ^{[1
,2
]}

Ables, Jessica L. ^{[3
]}

Lagace, Diane C. ^{[4
,5
]}

Nave, Klaus-Armin ^{[6
]}

Goebbels, Sandra ^{[6
]}

Eisch, Amelia J. ^{[3
]}

Hsieh, Jenny ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

[4] Univ Ottawa, Ctr Stroke Recovery, Dept Cellular & Mol Med, Ottawa, ON K1N 6N5, Canada

[5] Univ Ottawa, Ctr Stroke Recovery, Heart & Stroke Fdn, Ottawa, ON K1N 6N5, Canada

[6] Max Planck Inst Expt Med, Dept Neurogenet, D-37075 Gottingen, Germany

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 09期

基金：

美国国家卫生研究院;

关键词：

TRANSCRIPTION FACTOR; NEUROGENESIS; DIFFERENTIATION; MORPHOGENESIS; CELLS; GENE; MICE;

D O I：

10.1038/nn.2385

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

引用

页码：1090 / 1092

页数：3

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