Rethinking Differentiation: Stem Cells, Regeneration, and Plasticity

被引：231

作者：

Alvarado, Alejandro Sanchez ^{[1
,2
]}

Yamanaka, Shinya ^{[3
,4
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

[2] Howard Hughes Med Inst, Kansas City, MO 64110 USA

[3] Kyoto Univ, Ctr iPS Cell Res & Applicat CiRA, Kyoto 606, Japan

[4] Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

来源：

CELL | 2014年 / 157卷 / 01期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

SEE VOL. 511; SOMATIC-CELLS; REVERSE DEVELOPMENT; SMALL-INTESTINE; PG; 112; FIBROBLASTS; PLURIPOTENCY; ARABIDOPSIS; EXPRESSION; HOMEOSTASIS;

D O I：

10.1016/j.cell.2014.02.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it means to be a stem or a differentiated cell. Past and recent discoveries in plants and animals, as well as novel experimental manipulations, are beginning to erode many of these established concepts and are forcing a re-evaluation of the experimental systems and paradigms presently being used to explore these and other biological process.

引用

页码：110 / 119

页数：10

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