A DFT study of the full catalytic cycle of the Suzuki-Miyaura cross-coupling on a model system

被引:337
作者
Braga, Ataualpa A. C.
Ujaque, Gregori
Maseras, Feliu [1 ]
机构
[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Catalonia, Spain
[2] Univ Autonoma Barcelona, Unitat Quim Fis, Bellaterra 08193, Catalonia, Spain
关键词
D O I
10.1021/om060380i
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A computational study with the Becke3LYP DFT functional is carried out on the cross-coupling reaction of vinyl bromide H2C = CHBr and vinylboronic acid H2C = CHB(OH)(2) catalyzed by palladium diphosphine [Pd(PH3)(2)] in the presence of an excess of base OH-. The full catalytic cycle is computed, starting from the separated reactants and the catalyst and finishing with the cross-coupled product and the regeneration of the catalyst. The different stages in the cycle (oxidative addition, isomerization, transmetalation, reductive elimination) are characterized through calculation of the corresponding intermediates and transition states. Different alternative mechanisms are considered, depending on the number of phosphine ligands at palladium, and on the cis or trans isomery around the metal center. The results indicate the existence of a number of competitive pathways of reasonably low energy.
引用
收藏
页码:3647 / 3658
页数:12
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