Effects of MCH/NEI in the striatum and interactions between them and with α-MSH on IP3 levels

被引：3

作者：

Sanchez, MS ^{[1
]}

Berberian, V ^{[1
]}

Celis, ME ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farmacol, Lab Fisiol, RA-5000 Cordoba, Argentina

来源：

PEPTIDES | 2002年 / 23卷 / 05期

关键词：

IP3; alpha-MSH; MCH; NEI; striatum; brain slices;

D O I：

10.1016/S0196-9781(02)00013-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we investigated: (a) the effect of melanocyte concentrating hormone (MCH) and neuropeptide glutamine (E)-isoleusine-(I) (NEI) on IP3 production on an "in vitro" model using slices containing caudate putamen (CP) and accumbens nuclei (ACC); and (b) the interaction between these peptides and with alpha-melanocyte-stimulating-hormone (alpha-MSH) on the production of this second messenger. Only MCH at the highest dose studied (3.6 muM) increased the production of IP3, whereas at the low concentration (0.6 muM) it did not affect IP3 levels. NEI and alpha-MSH at both concentrations tested (0.6 and 3.6 muM), did not affect IP3 production either. However, when NEI or alpha-MSH (at 3.6 muM) were added together with 3.6 muM MCH, the increase in the IP3 content induced by this last peptide was blocked. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：877 / 880

页数：4

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