Medicinal strategies in the treatment of obesity

被引:311
作者
Bray, GA
Tartaglia, LA
机构
[1] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA
[2] Millennium Pharmaceut Inc, Cambridge, MA 02139 USA
关键词
D O I
10.1038/35007544
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 [理学]; 0710 [生物学]; 09 [农学];
摘要
When prevention fails, medicinal treatment of obesity may become a necessity Any strategic medicinal development must recognize that obesity is a chronic, stigmatized and costly disease that is increasing in prevalence. Because obesity can rarely be cured, treatment strategies are effective only as long as they are used, and combined therapy may be more effective than monotherapy. For a drug to have significant impact on body weight it must ultimately reduce energy intake, Increase energy expenditure, or both, Currently approved drugs for long-term treatment of obesity include sibutramine, which inhibits food intake, and orlistat, which blocks fat digestion.
引用
收藏
页码:672 / 677
页数:6
相关论文
共 93 条
[1]
Annual deaths attributable to obesity in the United States [J].
Allison, DB ;
Fontaine, KR ;
Manson, JE ;
Stevens, J ;
VanItallie, TB .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (16) :1530-1538
[2]
[Anonymous], [No title captured]
[3]
Long-term maintenance of weight loss after a very-low-calorie diet: A randomized blinded trial of the efficacy and tolerability of sibutramine [J].
Apfelbaum, M ;
Vague, P ;
Ziegler, O ;
Hanotin, C ;
Thomas, F ;
Leutenegger, E .
AMERICAN JOURNAL OF MEDICINE, 1999, 106 (02) :179-184
[4]
ASTRUP A, 1992, INT J OBESITY, V16, P269
[5]
THE EFFECT OF EPHEDRINE CAFFEINE MIXTURE ON ENERGY-EXPENDITURE AND BODY-COMPOSITION IN OBESE WOMEN [J].
ASTRUP, A ;
BUEMANN, B ;
CHRISTENSEN, NJ ;
TOUBRO, S ;
THORBEK, G ;
VICTOR, OJ ;
QUAADE, F .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1992, 41 (07) :686-688
[6]
ENHANCED THERMOGENIC RESPONSIVENESS DURING CHRONIC EPHEDRINE TREATMENT IN MAN [J].
ASTRUP, A ;
LUNDSGAARD, C ;
MADSEN, J ;
CHRISTENSEN, NJ .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1985, 42 (01) :83-94
[7]
Opioid receptor subtype control of galanin-induced feeding [J].
Barton, C ;
York, DA ;
Bray, GA .
PEPTIDES, 1996, 17 (02) :237-240
[8]
Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor [J].
Bjorbæk, C ;
Elmquist, JK ;
El-Haschimi, K ;
Kelly, J ;
Ahima, RS ;
Hileman, S ;
Flier, JS .
ENDOCRINOLOGY, 1999, 140 (05) :2035-2043
[9]
Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression [J].
Boss, O ;
Samec, S ;
PaoloniGiacobino, A ;
Rossier, C ;
Dulloo, A ;
Seydoux, J ;
Muzzin, P ;
Giacobino, JP .
FEBS LETTERS, 1997, 408 (01) :39-42
[10]
Bray G, 1998, AM J CLIN NUTR, V67, P1