Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4)

被引：39

作者：

Cao, GT ^{[1
]}

Ni, XH ^{[1
]}

Jiang, M ^{[1
]}

Ma, YS ^{[1
]}

Cheng, HP ^{[1
]}

Guo, LC ^{[1
]}

Ji, CN ^{[1
]}

Gu, SH ^{[1
]}

Xie, Y ^{[1
]}

Mao, YM ^{[1
]}

机构：

[1] Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

来源：

JOURNAL OF HUMAN GENETICS | 2002年 / 47卷 / 07期

关键词：

CREB4; MTC panel PCR; chromosome; 1q21.3; leucine zipper; transcription activator;

D O I：

10.1007/s100380200053

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Cyclic adenosine monophosphate (cAMP) response element-binding (CREB) proteins are a family of mammalian transcription activators. We identified a novel human CREB gene (CREB4) that was 1592bp long and encoded a protein of 395 amino acid residues. The protein shared high homology to mouse CREB3 (identity 62%, similarity 72%). The expression pattern of the human CREB4 gene showed transcripts in prostate, brain, pancreas, skeletal muscle, small intestine, testis, leukocyte, and thymus, whereas in heart, lung, liver, kidney, placenta, spleen, ovary, and colon, specific bands of the transcript could not be detected. The CREB4 gene consisted of ten exons and nine introns and was mapped to chromosome 1q21.3 by means of a bioinformatics analysis.

引用

页码：373 / 376

页数：4

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