Decreased sperm function of patients with myotonic muscular dystrophy

被引：26

作者：

Hortas, ML ^{[1
]}

Castilla, JA

Gil, MT

Molina, J

Garrido, ML

Morell, M

Redondo, M

机构：

[1] Hosp Costa Sol, Unidad Analisis Clinicos, Marbella 29600, Spain

[2] Hosp Virgen Nieves, Unidad Reprod, Granada 18014, Spain

[3] Hosp Na Sra Prado, Serv Analisis Clinicos, Talavera De La Reina, Spain

[4] Univ Malaga, Dept Bioquim & Biol Mol, Malaga 29080, Spain

来源：

HUMAN REPRODUCTION | 2000年 / 15卷 / 02期

关键词：

acrosome reaction; dystrophy; D-mannose; spermatozoa;

D O I：

10.1093/humrep/15.2.445

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Myotonic muscular dystrophy (MMD) is a genetic disease caused by a defective enzyme, myotoninkinase. Male patients with MMD are reported to have reduced fertility. The purpose of this work was to study sperm capacitation and acrosome reaction in the ejaculates of sterile males with MMD and of healthy males (control group). The expression of the specific D-mannose receptors was explored by microscopic examination and by flow cytometry analysis. In addition, the binding patterns of Pisum sativum (PSA) lectin to acrosome content and outer acrosomal membrane in the spermatazoa of each group were analysed. Both the capacitation and the acrosome reaction in the spermatozoa of the MMD group were deficient and these findings strongly suggest that these anomalies may account for the sterility of these patients.

引用

页码：445 / 448

页数：4

共 20 条

[1] ANTISPERM ANTIBODY-BINDING TO HUMAN SPERM INHIBITS CAPACITATION INDUCED CHANGES IN THE LEVELS OF PLASMA-MEMBRANE STEROLS [J].

BENOFF, S ;

COOPER, GW ;

HURLEY, I ;

MANDEL, FS ;

ROSENFELD, DL .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1993, 30 (2-3) :113-130

[2] HEAD-SPECIFIC MANNOSE LIGAND-RECEPTOR EXPRESSION IN HUMAN SPERMATOZOA IS DEPENDENT ON CAPACITATION-ASSOCIATED MEMBRANE CHOLESTEROL LOSS [J].

BENOFF, S ;

HURLEY, I ;

COOPER, GW ;

MANDEL, FS ;

ROSENFELD, DL ;

HERSHLAG, A .

HUMAN REPRODUCTION, 1993, 8 (12) :2141-2154

[3]

BENOFF S, 1993, FERTIL STERIL, V59, P854

[4] Modelling human sperm-egg interactions in vitro: signal transduction pathways regulating the acrosome reaction [J].

Benoff, S .

MOLECULAR HUMAN REPRODUCTION, 1998, 4 (05) :453-471

[5]

BENOFF S, 1993, HUM REPROD, V8, P2155, DOI 10.1093/oxfordjournals.humrep.a137997

[6]

BENOFF S, 1993, HUM REPROD, V8, P200

[7] DETECTION OF AN UNSTABLE FRAGMENT OF DNA SPECIFIC TO INDIVIDUALS WITH MYOTONIC-DYSTROPHY [J].

BUXTON, J ;

SHELBOURNE, P ;

DAVIES, J ;

JONES, C ;

VANTONGEREN, T ;

ASLANIDIS, C ;

DEJONG, P ;

JANSEN, G ;

ANVRET, M ;

RILEY, B ;

WILLIAMSON, R ;

JOHNSON, K .

NATURE, 1992, 355 (6360) :547-548

[8]

De Jonge C. J, 1994, REPROD MED REV, V3, P159

[9] Carbohydrate binding activity in human spermatozoa: localization, specificity, and involvement in sperm-egg fusion [J].

Gabriele, A ;

D'Andrea, G ;

Cordeschi, G ;

Properzi, G ;

Giammatteo, M ;

De Stefano, C ;

Romano, R ;

Francavilla, F ;

Francavilla, S .

MOLECULAR HUMAN REPRODUCTION, 1998, 4 (06) :543-553

[10] EXPANSION OF AN UNSTABLE DNA REGION AND PHENOTYPIC VARIATION IN MYOTONIC-DYSTROPHY [J].

HARLEY, HG ;

BROOK, JD ;

RUNDLE, SA ;

CROW, S ;

REARDON, W ;

BUCKLER, AJ ;

HARPER, PS ;

HOUSMAN, DE ;

SHAW, DJ .

NATURE, 1992, 355 (6360) :545-546

← 1 2 →