Synergy between LRH-1 and β-catenin induces G1 cyclin-mediated cell proliferation

被引：257

作者：

Botrugno, OA

Fayard, E

Annicotte, JS

Haby, C

Brennan, T

Wendling, O

Tanaka, T

Kodama, T

Thomas, W

Auwerx, J ^{[1
]}

Schoonjans, K

机构：

[1] Univ Strasbourg 1, Inst Genet & Biol Mol & Cellulaire, Ctr Natl Rech Sci, Inst Natl Sante & Rech Med, F-67404 Illkirch Graffenstaden, France

[2] Deltagen Inc, Menlo Pk, CA 94025 USA

[3] Inst Clin Souris, F-67404 Illkirch Graffenstaden, France

[4] Univ Tokyo, Adv Sci & Technol Res Ctr, Tokyo 1538904, Japan

来源：

MOLECULAR CELL | 2004年 / 15卷 / 04期

关键词：

D O I：

10.1016/j.molcel.2004.07.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LRH-1 is an orphan nuclear receptor predominantly expressed in tissues of endodermal origin, where it controls development and cholesterol homeostasis. We show here that LRH-1 induces cell proliferation through the concomitant induction of cyclin D1 and Ell, an effect that is potentiated by its interaction with beta-catenin. Whereas beta-catenin coactivates LRH-1 on the cyclin El promoter, LRH-1 acts as a potent tissue-restricted coactivator of beta-catenin on the cyclin D1 promoter. The implication of LRH-1 in cell proliferation highlights an unanticipated crosstalk between LRH-1 and the beta-catenin/Tcf4 signaling pathway, which is relevant for the renewal of intestinal crypt cells.

引用

页码：499 / 509

页数：11

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