The metastatic niche: adapting the foreign soil

被引：976

作者：

Psaila, Bethan ^{[1
,2
]}

Lyden, David ^{[1
,3
,4
]}

机构：

[1] Weill Cornell Med Coll, Dept Pediat & Cell & Dev Biol, New York, NY 10021 USA

[2] Imperial Coll London, Dept Haematol, Fac Med, London W12 0NN, England

[3] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[4] Champalimaud Fdn, Champalimaud Metastasis Ctr, P-050094 Lisbon, Portugal

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 04期

关键词：

STEM-CELL NICHE; BREAST-CANCER METASTASIS; MARROW-DERIVED CELLS; EXPERIMENTAL MELANOMA METASTASIS; HEPATIC STELLATE CELLS; LUNG METASTASIS; HEMATOPOIETIC STEM; TUMOR ANGIOGENESIS; MYELOID CELLS; IN-VIVO;

D O I：

10.1038/nrc2621

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The 'seed and soil' hypothesis for metastasis sets forth the concept that a conducive microenvironment, or niche, is required for disseminating tumour cells to engraft distant sites. This Opinion presents emerging data that support this concept and outlines the potential mechanism and temporal sequence by which changes occur in tissues distant from the primary tumour. To enable improvements in the prognosis of advanced malignancy, early interventions that target both the disseminating seed and the metastatic soil are likely to be required.

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收藏

页码：285 / 293

页数：9

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