Integrative medicine: Breaking down silos of knowledge and practice an epigenetic approach

被引:21
作者
McEwen, Bruce S. [1 ]
机构
[1] Rockefeller Univ, Neuroendocrinol Lab, 1230 York Ave, New York, NY 10065 USA
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2017年 / 69卷
基金
英国生物技术与生命科学研究理事会;
关键词
Humanistic medicine; Adverse childhood experiences; Depression; Multi-morbidity; Resilience; ADVERSE CHILDHOOD EXPERIENCES; ADULT NEUROGENESIS; STRUCTURAL PLASTICITY; COGNITIVE DECLINE; MAJOR DEPRESSION; HEALTH-PROMOTION; SYSTEMS MEDICINE; CHRONIC STRESS; DENTATE GYRUS; PSA-NCAM;
D O I
10.1016/j.metabol.2017.01.018
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
The future of medicine is discussed in the context of epigenetic influences during the entire life course and the lived experiences of each person, avoiding as much as possible the "medicalization" of the individual and taking a more humanistic view. The reciprocal communication between brain and body via the neuroendocrine, autonomic, metabolic and immune systems and the plasticity of brain architecture provide the basis for devising better "top down" interventions that engage the whole person in working towards his or her welfare. The life course perspective emphasizes the importance of intervening early in life to prevent adverse early life experiences, including the effects of poverty, that can have lifelong consequences, referred to as "biological embedding". In the spirit of integrative, humanistic medicine, treatments that "open windows of plasticity" allow targeted behavioral interventions to redirect brain and body functions and behavior in healthier directions. Policies of government and the private sector, particularly at the local, community level, can create a supporting environment for such interventions. See "Common Ground for Health: Personalized, Precision and Social Medicine McEwen & Getz (C) 2017 Published by Elsevier Inc.
引用
收藏
页码:S21 / S29
页数:9
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