Solubilization of substituted indole compounds by β-cyclodextrin in water

被引：13

作者：

Cao, JS ^{[1
]}

Zhao, CL ^{[1
]}

Huang, LM ^{[1
]}

Ding, YB ^{[1
]}

Wang, LS ^{[1
]}

Han, SK ^{[1
]}

机构：

[1] China Univ Min & Technol, Dept Energy Resources Utilizat & Organ Chem Engn, Xuzhou 221008, Peoples R China

来源：

CHEMOSPHERE | 2000年 / 40卷 / 12期

基金：

中国国家自然科学基金;

关键词：

substituted indole compounds; beta-cyclodextrin; inclusion complex; stability;

D O I：

10.1016/S0045-6535(99)00321-5

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The solubilization of four pairs of substituted indole compounds (SICs) by beta-cyclodextrin (beta-CD) in water was investigated. The results show that 1,2,3,4-tetrahydrocarbazole and N-methyl-1,2,3,4-tetrahydrocarbazole form 1:1 inclusion complexes with P-CD, while the other six SICs form 1:2 inclusion complexes, respectively. To each pair of SICs with similar structures, the differences between their solubilization in beta-cD/water solutions has been explained by the difference of their contact area within the beta-CD cavity, the difference of their molecule polarity, or the presence of hydrogen bond between SIC molecule and beta-CD molecule. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1411 / 1416

页数：6

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