Metabolic profiling identifies lung tumor responsiveness to erlotinib

被引：25

作者：

Fan, Teresa W. -M. ^{[1
,2
]}

Lane, Andrew N. ^{[1
]}

Higashi, Richard M. ^{[1
,2
]}

Bousamra, Michael, II ^{[3
]}

Kloecker, Goetz ^{[1
]}

Miller, Donald M. ^{[1
]}

机构：

[1] Univ Louisville, James Graham Brown Canc Ctr, Dept Med, Louisville, KY 40202 USA

[2] Univ Louisville, Dept Chem, Louisville, KY 40208 USA

[3] Univ Louisville, Dept Surg, Louisville, KY 40202 USA

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2009年 / 87卷 / 01期

基金：

美国国家科学基金会;

关键词：

Bronchioalveolar adenocarcinoma; Metabolomics; Erlotinib; BRONCHIOLOALVEOLAR CARCINOMA; CANCER CELLS; MUTATIONS; GLYCOLYSIS; SURVIVAL; THERAPY; NMR;

D O I：

10.1016/j.yexmp.2009.04.004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A subtype of non-small cell lung cancer, bronchioalveolar adenocarcinoma (BAC), is more prevalent in Asian female non-smokers, and is more likely to respond to treatment with tyrosine kinase inhibitors such as erlotinib and gefitinib. Nuclear magnetic resonance and mass spectrometry-based metabolomic analysis of extracts from two different lung lesions and surrounding non-cancerous tissues of a BAC patient showed novel protein and phospholipid-associated metabolic differences that correlated with tumor development as well as PET and erlotinib sensitivity. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：83 / 86

页数：4

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