Murine tumor necrosis factor-α sensitizes plasma corticosterone activity and the manifestation of shock:: modulation by histamine

被引：19

作者：

Hayley, S ^{[1
]}

Kelly, O ^{[1
]}

Anisman, H ^{[1
]}

机构：

[1] Carleton Univ, Inst Neurosci, Ottawa, ON K1S 5B6, Canada

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 131卷 / 1-2期

基金：

加拿大健康研究院;

关键词：

histamine; TNF-alpha; sensitization; corticosterone; sickness; shock;

D O I：

10.1016/S0165-5728(02)00259-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Murine tumor necrosis factor-alpha (mTNF-alpha) results in the sensitization of mechanisms underlying plasma corticosterone activity and sickness behavior, the latter being reminiscent of septic or anaphylactic shock. The mTNF-alpha induced a sensitization of sickness and corticosterone in mice that was attenuated by pretreatment with the combinations of histamine H-1 (diphenhydramine, mepyramine) and H-2 (cimetidine) antagonists. Likewise, coadministration of diphenhydramine and cimetidine prevented the mTNF-alpha-provoked rise of monoamine activity within the posterior hypothalamus. Although dexamethasone ameliorated the mTNF-alpha-induced sensitization of corticosterone, illness behavior was unaffected. It is suggested that mTNF-alpha-induced illness and the neuroendocrine sensitization are mediated by endogenous histamine. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：60 / 69

页数：10

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