Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease

被引：492

作者：

Fasano, A ^{[1
]}

Not, T

Wang, WL

Uzzau, S

Berti, I

Tommasini, A

Goldblum, SE

机构：

[1] Univ Maryland, Dept Vet Affairs Med Ctr, Sch Med, Div Paediat Gastroenterol & Nutr, Baltimore, MD 21201 USA

[2] Univ Maryland, Dept Vet Affairs Med Ctr, Sch Med, Ctr Vaccine Dev,Gastrointestinal Pathophysiol Sec, Baltimore, MD 21201 USA

[3] Univ Maryland, Dept Vet Affairs Med Ctr, Sch Med, Dept Physiol, Baltimore, MD 21201 USA

[4] Univ Maryland, Dept Vet Affairs Med Ctr, Sch Med, Div Infect Dis, Baltimore, MD 21201 USA

[5] Univ Trieste, IRCCS Burlo Garofolo, Pediat Clin, I-34127 Trieste, Italy

来源：

LANCET | 2000年 / 355卷 / 9214期

关键词：

D O I：

10.1016/S0140-6736(00)02169-3

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in nonhuman primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.

引用

页码：1518 / 1519

页数：2

共 5 条

[1]

The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway [J].