Nicotinic antagonists (piperidines and quinuclidines) reduce the susceptibility of early sea urchin embryos to agents evoking calcium shock

被引：7

作者：

Buznikov, GA

Koikov, LN

Shmukler, YB

Whitaker, MJ

机构：

[1] ALL RUSSIAN RES INST CHEM & PHARMACOL, CTR DRUG CHEM, MOSCOW, RUSSIA

[2] UNIV NEWCASTLE, DEPT PHYSIOL SCI, NEWCASTLE UPON TYNE, TYNE & WEAR, ENGLAND

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1997年 / 29卷 / 01期

关键词：

early embryos; nicotinic choline receptors;

D O I：

10.1016/S0306-3623(96)00524-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Some nicotinic antagonists (piperidine and quinuclidine derivatives and bis-quaternary compounds) protect early embryos of the sea urchin Lytechinus pictus against a calcium shock evoked by ionomycin or a mixture of phorbol myristate acetate and nicotine. 2. Maximal protective potency was found for drugs that did not penetrate the plasma membrane. 3. Early sea urchin embryos have nicotinic acetylcholine receptors (nAChR) or nAChR-like structures localized on the cell surface that, apparently, take part in the control of Ca2+ influx. (C) 1997 Elsevier Science Inc.

引用

页码：49 / 53

页数：5

共 26 条

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