Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

被引：912

作者：

Semenza, Gregg L. ^{[1
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机构：

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Vasc Program, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9 | 2014年 / 9卷

关键词：

bronchiolitis obliterans; cardioprotection; collateral vessels; polycythemia; preconditioning; retinopathy; ENDOTHELIAL GROWTH-FACTOR; CORONARY-HEART-DISEASE; RENAL-CELL-CARCINOMA; FACTOR; 1-ALPHA; FACTOR-I; BREAST-CANCER; TRANSCRIPTIONAL ACTIVITY; UNFAVORABLE PROGNOSIS; TUMOR ANGIOGENESIS; CAROTID-BODY;

D O I：

10.1146/annurev-pathol-012513-104720

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory system and in cancer. The role of HIFs in these diseases has been elucidated by clinical studies and by analyses of mouse models. HIFs play a protective role in the pathophysiology of myocardial ischemia due to coronary artery disease, limb ischemia due to peripheral arterial disease, pressure-overload heart failure, wound healing, and chronic rejection of organ transplants. In contrast, HIFs contribute to the pathogenesis of pulmonary arterial hypertension, systemic hypertension associated with sleep apnea, ocular neovascularization, hereditary erythrocytosis, and cancer.

引用

页码：47 / 71

页数：25

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