Every Cell Is Special: Genome-wide Studies Add a New Dimension to Single-Cell Biology

被引：183

作者：

Junker, Jan Philipp ^{[1
,2
]}

van Oudenaarden, Alexander ^{[1
,2
]}

机构：

[1] KNAW, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, NL-3584 CT Utrecht, Netherlands

来源：

CELL | 2014年 / 157卷 / 01期

关键词：

RNA-SEQ; EXPRESSION; AMPLIFICATION; IMMUNE; NOISE;

D O I：

10.1016/j.cell.2014.02.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Single-cell analyses have provided invaluable insights into studying heterogenity, signaling, and stochastic gene expression. Recent technological advances now open the door to genome-wide single-cell studies.

引用

页码：8 / 11

页数：4

共 23 条

[1]

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum [J].

Bendall, Sean C. ;

Simonds, Erin F. ;

Qiu, Peng ;

Amir, El-ad D. ;

Krutzik, Peter O. ;

Finck, Rachel ;

Bruggner, Robert V. ;

Melamed, Rachel ;

Trejo, Angelica ;

Ornatsky, Olga I. ;

Balderas, Robert S. ;

Plevritis, Sylvia K. ;

Sachs, Karen ;

Pe'er, Dana ;

Tanner, Scott D. ;

Nolan, Garry P. .

SCIENCE, 2011, 332 (6030) :687-696

[2]

Brennecke P, 2013, NAT METHODS, V10, P1093, DOI [10.1038/NMETH.2645, 10.1038/nmeth.2645]

[3]

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase [J].

Buganim, Yosef ;

Faddah, Dina A. ;

Cheng, Albert W. ;

Itskovich, Elena ;

Markoulaki, Styliani ;

Ganz, Kibibi ;

Klemm, Sandy L. ;

van Oudenaarden, Alexander ;

Jaenisch, Rudolf .

CELL, 2012, 150 (06) :1209-1222

[4]

Comprehensive human genome amplification using multiple displacement amplification [J].

Dean, FB ;

Hosono, S ;

Fang, LH ;

Wu, XH ;

Faruqi, AF ;

Bray-Ward, P ;

Sun, ZY ;

Zong, QL ;

Du, YF ;

Du, J ;

Driscoll, M ;

Song, WM ;

Kingsmore, SF ;

Egholm, M ;

Lasken, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5261-5266

[5]

CEL-Seq: Single-Cell RNA-Seq by Multiplexed Linear Amplification [J].

Hashimshony, Tamar ;

Wagner, Florian ;

Sher, Noa ;

Yanai, Itai .

CELL REPORTS, 2012, 2 (03) :666-673

[6]

Islam S, 2014, NAT METHODS, V11, P163, DOI [10.1038/NMETH.2772, 10.1038/nmeth.2772]

[7]

Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq [J].

Islam, Saiful ;

Kjallquist, Una ;

Moliner, Annalena ;

Zajac, Pawel ;

Fan, Jian-Bing ;

Lonnerberg, Peter ;

Linnarsson, Sten .

GENOME RESEARCH, 2011, 21 (07) :1160-1167

[8]

Kivioja T, 2012, NAT METHODS, V9, P72, DOI [10.1038/NMETH.1778, 10.1038/nmeth.1778]

[9]

Parallel Visualization of Multiple Protein Complexes in Individual Cells in Tumor Tissue [J].

Leuchowius, Karl-Johan ;

Clausson, Carl-Magnus ;

Grannas, Karin ;

Erbilgin, Yucel ;

Botling, Johan ;

Zieba, Agata ;

Landegren, Ulf ;

Soderberg, Ola .

MOLECULAR & CELLULAR PROTEOMICS, 2013, 12 (06) :1563-1571

[10]

Mosaic Copy Number Variation in Human Neurons [J].

McConnell, Michael J. ;

Lindberg, Michael R. ;

Brennand, Kristen J. ;

Piper, Julia C. ;

Voet, Thierry ;

Cowing-Zitron, Chris ;

Shumilina, Svetlana ;

Lasken, Roger S. ;

Vermeesch, Joris R. ;

Hall, Ira M. ;

Gage, Fred H. .

SCIENCE, 2013, 342 (6158) :632-637

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