ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

被引：4414

作者：

Scheffer, Ingrid E. ^{[1
,2
,3
]}

Berkovic, Samuel ^{[1
]}

Capovilla, Giuseppe ^{[4
]}

Connolly, Mary B. ^{[5
]}

French, Jacqueline ^{[6
]}

Guilhoto, Laura ^{[7
,8
]}

Hirsch, Edouard ^{[9
,10
]}

Jain, Satish ^{[11
]}

Mathern, Gary W. ^{[12
,13
]}

Moshe, Solomon L. ^{[14
,15
,16
]}

Nordli, Douglas R. ^{[17
]}

Perucca, Emilio ^{[18
,19
]}

Tomson, Torbjoern ^{[20
]}

Wiebe, Samuel ^{[21
,22
]}

Zhang, Yue-Hua ^{[23
]}

Zuberi, Sameer M. ^{[24
,25
]}

机构：

[1] Univ Melbourne, Dept Med, Austin Hlth, Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Paediat, Royal Childrens Hosp, Melbourne, Vic, Australia

[3] Florey Inst, Melbourne, Vic, Australia

[4] C Poma Hosp, Child Neuropsychiat Dept, Epilepsy Ctr, Mantua, Italy

[5] Univ British Columbia, Dept Pediat, British Columbias Childrens Hosp, Vancouver, BC, Canada

[6] NYU, Dept Neurol, Sch Med, New York, NY 10016 USA

[7] Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, Brazil

[8] Univ Sao Paulo, Univ Hosp, Sao Paulo, Brazil

[9] Univ Hosp, INSERM, U 964, Strasbourg, France

[10] IDEE, Lyon, France

[11] Indian Epilepsy Ctr, New Delhi, India

[12] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA

[13] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Med, Los Angeles, CA 90095 USA

[14] Albert Einstein Coll Med, Saul R Korey Dept Neurol, Dominick P Purpura Dept Neurosci, Bronx, NY 10467 USA

[15] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA

[16] Montefiore Med Ctr, 111 E 210th St, Bronx, NY 10467 USA

[17] Childrens Hosp Los Angeles, Div Neurol, Los Angeles, CA 90027 USA

[18] Univ Pavia, C Mondino Natl Neurol Inst, Pavia, Italy

[19] Univ Pavia, Clin Pharmacol Unit, Pavia, Italy

[20] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[21] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada

[22] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada

[23] Peking Univ First Hosp, Dept Pediat, Beijing, Peoples R China

[24] Royal Hosp Children, Paediat Neurosci Res Grp, Fraser Allander Neurosci Unit, Glasgow, Lanark, Scotland

[25] Univ Glasgow, Sch Med, Glasgow, Lanark, Scotland

来源：

EPILEPSIA | 2017年 / 58卷 / 04期

基金：

英国医学研究理事会; 澳大利亚研究理事会; 美国国家卫生研究院;

关键词：

Classification; Epilepsy syndromes; Terminology; Etiology; DE-NOVO MUTATIONS; EPILEPTIC ENCEPHALOPATHIES; ETIOLOGIC CLASSIFICATION; 15Q13.3; MICRODELETIONS; LANGUAGE DYSFUNCTION; LOBE EPILEPSY; SEIZURES; ORGANIZATION; DEFINITION; DISORDERS;

D O I：

10.1111/epi.13709

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The International League Against Epilepsy (ILAE) Classification of the Epilepsies has been updated to reflect our gain in understanding of the epilepsies and their underlying mechanisms following the major scientific advances that have taken place since the last ratified classification in 1989. As a critical tool for the practicing clinician, epilepsy classification must be relevant and dynamic to changes in thinking, yet robust and translatable to all areas of the globe. Its primary purpose is for diagnosis of patients, but it is also critical for epilepsy research, development of antiepileptic therapies, and communication around the world. The new classification originates from a draft document submitted for public comments in 2013, which was revised to incorporate extensive feedback from the international epilepsy community over several rounds of consultation. It presents three levels, starting with seizure type, where it assumes that the patient is having epileptic seizures as defined by the new 2017 ILAE Seizure Classification. After diagnosis of the seizure type, the next step is diagnosis of epilepsy type, including focal epilepsy, generalized epilepsy, combined generalized, and focal epilepsy, and also an unknown epilepsy group. The third level is that of epilepsy syndrome, where a specific syndromic diagnosis can be made. The new classification incorporates etiology along each stage, emphasizing the need to consider etiology at each step of diagnosis, as it often carries significant treatment implications. Etiology is broken into six subgroups, selected because of their potential therapeutic consequences. New terminology is introduced such as developmental and epileptic encephalopathy. The term benign is replaced by the terms self-limited and pharmacoresponsive, to be used where appropriate. It is hoped that this new framework will assist in improving epilepsy care and research in the 21st century.

引用

页码：512 / 521

页数：10

共 58 条

[1]

PROPOSAL FOR REVISED CLASSIFICATION OF EPILEPSIES AND EPILEPTIC SYNDROMES [J].