Irritable Bowel Syndrome: A Practical Approach

被引：4

作者：

Clark, Christian ^{[1
]}

DeLegge, Mark ^{[1
]}

机构：

[1] Med Univ S Carolina, Div Gastroenterol & Hepatol, Ctr Digest Dis, Charleston, SC 29425 USA

来源：

NUTRITION IN CLINICAL PRACTICE | 2008年 / 23卷 / 03期

关键词：

colon; small intestine; visceral afferents; diarrhea; constipation; gastroenterology;

D O I：

10.1177/0884533608318107

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Irritable bowel syndrome accounts for approximately 2.7 million physician office visits yearly, although only 10%-30% of affected patients seek treatment. The disease is predominantly found in women 20-50 years of age. The etiology of irritable bowel syndrome is likely multifactorial: environmental factors, genetics, gut flora alterations, nervous system alterations (visceral hypersensitivity and motility abnormalities), and psychosocial stressors are thought to contribute. Treatment options are also quite diverse, including both pharmacologic and nonpharmacologic modalities. This article summarizes the proposed pathophysiology of and treatment options for irritable bowel syndrome. (Nutr Clin Pract. 2008;23:263-267)

引用

页码：263 / 267

页数：5

共 51 条

[1] Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation [J].

Attar, A ;

Lémann, M ;

Ferguson, A ;

Halphen, M ;

Boutron, MC ;

Flourié, B ;

Alix, E ;

Salmeron, M ;

Guillemot, F ;

Chaussade, S ;

Ménard, AM ;

Moreau, J ;

Naudin, G ;

Barthet, M .

GUT, 1999, 44 (02) :226-230

[2] Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome [J].

Barbara, G ;

Stanghellini, V ;

De Giorgio, R ;

Cremon, C ;

Cottrell, GS ;

Santini, D ;

Pasquinelli, G ;

Morselli-Labate, AM ;

Grady, EF ;

Bunnett, NW ;

Collins, SM ;

Corinalidesi, R .

GASTROENTEROLOGY, 2004, 126 (03) :693-702

[3] Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome [J].

Barbara, Giovanni ;

Wang, Bingxian ;

Stanghellini, Vincenzo ;

De Giorgio, Roberto ;

Cremon, Cesare ;

Di Nardo, Giovanni ;

Trevisani, Marcello ;

Campi, Barbara ;

Geppetti, Pierangelo ;

Tonini, Marcello ;

Bunnett, Nigel W. ;

Grundy, David ;

Corinaldesi, Roberto .

GASTROENTEROLOGY, 2007, 132 (01) :26-37

[4] AMITRIPTYLINE POTENTIATES MORPHINE ANALGESIA BY A DIRECT ACTION ON THE CENTRAL NERVOUS-SYSTEM [J].

BOTNEY, M ;

FIELDS, HL .

ANNALS OF NEUROLOGY, 1983, 13 (02) :160-164

[5] Intolerance to visceral distension in functional dyspepsia or irritable bowel syndrome: an organ specific defect or a pan intestinal dysregulation? [J].

Bouin, M ;

Lupien, F ;

Riberdy, M ;

Boivin, M ;

Plourde, V ;

Poitras, P .

NEUROGASTROENTEROLOGY AND MOTILITY, 2004, 16 (03) :311-314

[6] Pathobiology of visceral pain:: Molecular mechanisms and therapeutic implications III.: Visceral afferent pathways:: a source of new therapeutic targets for abdominal pain [J].

Buéno, L ;

Fioramonti, J ;

Garcia-Villar, R .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 278 (05) :G670-G676

[7] Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome [J].

Camilleri, M ;

Atanasova, E ;

Carlson, PJ ;

Ahmad, U ;

Kim, HJ ;

Viramontes, BE ;

McKinzie, S ;

Urrutia, R .

GASTROENTEROLOGY, 2002, 123 (02) :425-432

[8]

Camilleri M, 1999, ALIMENT PHARM THERAP, V13, P1149

[9] IRRITABLE BOWEL SYNDROME - RELATIONSHIP OF DISORDERS IN THE TRANSIT OF A SINGLE SOLID MEAL TO SYMPTOM PATTERNS [J].

CANN, PA ;

READ, NW ;

BROWN, C ;

HOBSON, N ;

HOLDSWORTH, CD .

GUT, 1983, 24 (05) :405-411

[10] Activation of the mucosal immune system in irritable bowel syndrome [J].

Chadwick, VS ;

Chen, WX ;

Shu, DR ;

Paulus, B ;

Bethwaite, P ;

Tie, A ;

Wilson, I .

GASTROENTEROLOGY, 2002, 122 (07) :1778-1783

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