Terahertz Pulse Imaging in reflection geometry of skin tissue using time domain analysis techniques

被引:36
作者
Woodward, RM [1 ]
Wallace, VP [1 ]
Cole, BE [1 ]
Pye, RJ [1 ]
Arnone, DD [1 ]
Linfield, EH [1 ]
Pepper, M [1 ]
机构
[1] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England
来源
CLINICAL DIAGNOSTIC SYSTEMS: TECHNOLOGIES AND INSTRUMENTATION | 2002年 / 4625卷
关键词
Terahertz Pulse Imaging; skin; cancer; inflammation; time domain;
D O I
10.1117/12.469785
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
We demonstrate the application of Terahertz Pulse Imaging (TPI) in reflection geometry for the study of skin tissue and related cancers. The terahertz frequency regime of 0.1-100THz excites the vibrational modes of molecules, allowing for spectroscopic investigation. The sensitivity of terahertz to polar molecules, such as water, makes TPI suitable for studying the hydration levels in the stratum corneum and the determination of the lateral spread of skin cancer pre-operatively. By studying the terahertz pulse shape in the time domain we have been able to differentiate between diseased and normal tissue for the study of basal cell carcinoma (BCC). Measurements on scar tissue, which is known to contain less water than the surrounding skin, and on regions of inflammation, show a clear contrast in the THz image compared to normal skin. We discuss the time domain analysis techniques used to classify the different tissue types. Basal cell carcinoma shows a positive terahertz contrast, and inflammation and scar tissue shows a negative terahertz contrast compared to normal tissue. This demonstrates for the first time the potential of TPI both in the study of skin cancer and inflammatory related disorders.
引用
收藏
页码:160 / 169
页数:10
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