Synthesis of Poly(acrylic acid) Nanogels and Application in Loading and Release of an Oligothiophene Fluorophore and Its Bovine Serum Albumin Conjugate

被引：14

作者：

Argentiere, Simona ^{[1
,2
]}

Blasi, Laura ^{[1
]}

Ciccarella, Giuseppe ^{[1
,3
]}

Barbarella, Giovanna ^{[4
]}

Cingolani, Roberto ^{[1
,3
]}

Gigli, Giuseppe ^{[1
,3
]}

机构：

[1] INFM, CNR, Natl Nanotechnol Labs, I-73100 Lecce, Italy

[2] Univ Salento, Inst Super, Univ Formaz Interdisciplinare Sez Nanosci, I-73100 Lecce, Italy

[3] Univ Salento, Dipartimento Ingn Innovaz, I-73100 Lecce, Italy

[4] ISOF, Area Ric, CNR, I-40129 Bologna, Italy

来源：

MACROMOLECULAR SYMPOSIA | 2009年 / 281卷

关键词：

loading and release; nanoparticles; oligothiophene; poly(acrylic acid); stimuli-sensitive polymers; DRUG-DELIVERY; PH; PROTEINS; MICROGELS; HYDROGEL; POLYMERIZATION; MICELLES; GENE;

D O I：

10.1002/masy.200950709

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Nanometer-sized poly(acrylic acid) (PAA) hydrogels were synthesized by emulsion polymerization of methyl acrylate and subsequent acid hydrolysis, and their pH-dependent swelling behaviour was studied by dynamic light scattering. To determine the suitability of PAA nanogels as pH-sensitive carriers for biomedical applications, loading and release of an oligothiophene fluorophore and its albumin conjugate onto the PAA nanogels were investigated as a function of pH by absorption and photoluminescence measurements. it was observed that loading and release processes of both the oligothiophene and its conjugate could be controlled by changing pH of their solutions.

引用

页码：69 / 76

页数：8

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