Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice

被引：165

作者：

Duvall, Craig L.

Taylor, W. Robert

Weiss, Daiana

Wojtowicz, Abigail M.

Guldberg, Robert E.

机构：

[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[2] Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA

[3] Vet Affairs Med Ctr, Atlanta, GA 30033 USA

[4] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 02期

关键词：

osteopontin; fracture healing; angiogenesis; mu CT; bone mechanics;

D O I：

10.1359/JBMR.061103

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

OPN is an ECM protein with diverse localization and functionality. The role of OPN during fracture healing was examined using wildtype and OPN-/- mice. Results showed that OPN plays an important role in regulation of angiogenesis, callus formation, and mechanical strength in early stages of healing and facilitates late stage bone remodeling and ECM organization.

引用

收藏

页码：286 / 297

页数：12

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